ArticleTuberculosis research and treatment2012
An Early Morning Sputum Sample Is Necessary for the Diagnosis of Pulmonary Tuberculosis, Even with More Sensitive Techniques: A Prospective Cohort Study among Adolescent TB-Suspects in Uganda.
Article in Tuberculosis research and treatment, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparison of sputum collection methods for tuberculosis diagnosis: a systematic review and pairwise and network meta-analysis.The Lancet. Global health · 2017Pooled it
- Triplicate Sputum Cultures for Efficacy Evaluation of Novel Antituberculosis Regimens.American journal of respiratory and critical care medicine · 2017Trial
- Risk factors for tuberculosis treatment outcomes: a statistical learning-based exploration using the SINAN database with incomplete observations.BMC medical informatics and decision making · 2025Article
- Detection of pulmonary tuberculosis through mobile X-ray based active case-finding in Pakistan: a retrospective analysis from programmatic screening of1 214 289 individuals from 2017 to 2021.BMJ global health · 2025Article
- Reduced bacillary load in elderly patients with active extrapulmonary and pulmonary tuberculosis in Peru: analysis of confirmatory culture after acid-fast bacilli test.Frontiers in microbiology · 2024Article
- Advances in TB testing.Advances in clinical chemistry · 2023Article
- Does the timing of saliva collection affect the diagnosis of SARS-CoV-2 infection?Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2022Article
- Performance of Xpert MTB/RIF and sputum microscopy compared to sputum culture for diagnosis of tuberculosis in seven hospitals in Indonesia.Frontiers in medicine · 2022Article
- Active tuberculosis case findings in Ghanaian health facilities: effectiveness and sensitivity of the symptoms-based screening tool.The Pan African medical journal · 2021Article
- Spot sputum samples are at least as good as early morning samples for identifying Mycobacterium tuberculosis.BMC medicine · 2017Article
- Comparison ofJournal of medical science and clinical research · 2017Article
- Diagnosis of active tuberculosis disease: From microscopy to molecular techniques.Journal of clinical tuberculosis and other mycobacterial diseases · 2016Review
- Who Has Mycobacterial Disease? A Cross Sectional Study in Agropastoral Communities in Tanzania.PloS one · 2016Article
- Comparative Yield of Different Diagnostic Tests for Tuberculosis among People Living with HIV in Western Kenya.PloS one · 2016Article
- Article
- Feasibility of establishing a biosafety level 3 tuberculosis culture laboratory of acceptable quality standards in a resource-limited setting: an experience from Uganda.Health research policy and systems · 2015Article
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15 authors.
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Abstract
The World Health Organization (WHO) recommends collection of two sputum samples for tuberculosis (TB) diagnosis, with at least one being an early morning (EM) using smear microscopy. It remains unclear whether this is necessary even when sputum culture is employed. Here, we determined the diagnostic yield from spot and the incremental yield from the EM sputum sample cultures among TB-suspected adolescents from rural Uganda. Sputum samples (both spot and early-morning) from 1862 adolescents were cultured by the Lowenstein-Jensen (LJ) and Mycobacterium Growth Indicator Tube (MGIT) methods. For spot samples, the diagnostic yields for TB were 19.0% and 57.1% with LJ and MGIT, respectively, whereas the incremental yields (not totals) of the early-morning sample were 9.5% and 42.9% (P < 0.001) with LJ and MGIT, respectively. Among TB-suspected adolescents in rural Uganda, the EM sputum culture has a high incremental diagnostic yield. Therefore, EM sputum in addition to spot sample culture is necessary for improved TB case detection.
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