ArticleJournal of obesity2012
All-cause mortality risk of metabolically healthy obese individuals in NHANES III.
Article in Journal of obesity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
72 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Association Between Metabolic Status and Risk of Cancer Among Patients With Obesity: Metabolically Healthy Obesity vs. Metabolically Unhealthy Obesity.Frontiers in nutrition · 2022Pooled it
- Pooled it
- A indicator of visceral adipose dysfunction to evaluate metabolic health in adult Chinese.Scientific reports · 2016Trial
- Effects of nutrition education on weight gain prevention: a randomized controlled trial.Nutrition journal · 2016Trial
- Metabolically normal obese people are protected from adverse effects following weight gain.The Journal of clinical investigation · 2015Trial
- Obesity, Metabolic Health, and Diabetic Complications in People With Type 1 Diabetes.Endocrinology, diabetes & metabolism · 2025Article
- Metabolically healthy obesity: from epidemiology and mechanisms to clinical implications.Nature reviews. Endocrinology · 2024Review
- Relationship between Body Adiposity Indices and Reversal of Metabolically Unhealthy Obesity 6 Months after Roux-en-Y Gastric Bypass.Metabolites · 2024Article
- Article
- Cardiometabolic profiles and proteomics associated with obesity phenotypes in a longitudinal cohort of young adults.Scientific reports · 2024Article
- Triptolide Administration Alters Immune Responses to Mitigate Insulin Resistance in Obese States.Biomolecules · 2024Article
- Longitudinal study on metabolic abnormalities and diabetes risk in normal-weight japanese adults.Frontiers in endocrinology · 2024Article
- Trends and characteristics of the metabolically healthy obese phenotype in an Arab population.Frontiers in public health · 2024Article
- Investigating Adiposity-Related Metabolic Health Phenotypes in Patients with Hidradenitis Suppurativa: A Cross-Sectional Study.Journal of clinical medicine · 2023Article
- Metabolically defined body size and body shape phenotypes and risk of postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition.Cancer medicine · 2023Article
- A novel criterion of metabolically healthy obesity could effectively identify individuals with low cardiovascular risk among Chinese cohort.Frontiers in endocrinology · 2023Article
- Metabolically Healthy Obesity: Epidemiology, Criteria, and Implications in Chronic Kidney Disease.Journal of obesity & metabolic syndrome · 2022Review
- Prevalence rates of metabolic health and body size phenotypes by different criteria and association with insulin resistance in a Maltese Caucasian population.BMC endocrine disorders · 2022Article
- Sex differences in cardiometabolic abnormalities in a middle-aged Maltese population.Canadian journal of public health = Revue canadienne de sante publique · 2022Article
- Independent and joint effects of body mass index and metabolic health in mid- and late-life on all-cause mortality: a cohort study from the Swedish Twin Registry with a mean follow-up of 13 Years.BMC public health · 2022Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Mortality risk across metabolic health-by-BMI categories in NHANES-III was examined. Metabolic health was defined as: (1) homeostasis model assessment-insulin resistance (HOMA-IR) <2.5; (2) ≤2 Adult Treatment Panel (ATP) III metabolic syndrome criteria; (3) combined definition using ≤1 of the following: HOMA-IR ≥1.95 (or diabetes medications), triglycerides ≥1.7 mmol/L, HDL-C <1.04 mmol/L (males) or <1.30 mmol/L (females), LDL-C ≥2.6 mmol/L, and total cholesterol ≥5.2 mmol/L (or cholesterol-lowering medications). Hazard ratios (HR) for all-cause mortality were estimated with Cox regression models. Nonpregnant women and men were included (n = 4373, mean ± SD, age 37.1 ± 10.9 years, BMI 27.3 ± 5.8 kg/m², 49.4% female). Only 40 of 1160 obese individuals were identified as MHO by all definitions. MHO groups had superior levels of clinical risk factors compared to unhealthy individuals but inferior levels compared to healthy lean groups. There was increased risk of all-cause mortality in metabolically unhealthy obese participants regardless of definition (HOMA-IR HR 2.07 (CI 1.3-3.4), P < 0.01; ATP-III HR 1.98 (CI 1.4-2.9), P < 0.001; combined definition HR 2.19 (CI 1.3-3.8), P < 0.01). MHO participants were not significantly different from healthy lean individuals by any definition. While MHO individuals are not at significantly increased risk of all-cause mortality, their clinical risk profile is worse than that of metabolically healthy lean individuals.
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Registered trials
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