Evidence map›Paper›PMID 23304404›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2012

Selecting cases for whom additional tests can improve prognostication.

Xiaoqian Jiang, Jihoon Kim, Yuan Wu, Shuang Wang, Lucila Ohno-Machado

Abstract read
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaoqian JiangDivision of Biomedical Informatics, Department of Medicine University of California at San Diego, La Jolla, CA 92093, USA.
Jihoon Kim
Yuan Wu
Shuang Wang
Lucila Ohno-Machado

Funding

iDASH: Integrating Data for Analysis, Anonymization, and SharingU54HL108460 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OHNO-MACHADO, LUCILA · 2010 to 2015
$19.1M
SAN DIEGO CLINICAL AND TRANSLATIONAL RESEARCH INSTITUTEUL1RR031980 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2010 to 2011
$14.0M
SCANNER: Scalable National Network for Effectiveness ResearchR01HS019913 · AHRQ · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OHNO-MACHADO, LUCILA · 2010 to 2010
$8.3M
Assessing quality of individual predictions in medical decision support systemsR01LM009520 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OHNO-MACHADO, LUCILA · 2007 to 2010
$1.4M
Protection of Records: Privacy (PReP) Technology for Medical ResearchK99LM011392 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JIANG, XIAOQIAN · 2012 to 2012
$76k
AHRQ HHS R01 HS019913AHRQ HHS R01HS019913NCRR NIH HHS UL1 RR031980NCRR NIH HHS UL1RR031980NHLBI NIH HHS U54 HL108460NLM NIH HHS 1K99LM011392-01NLM NIH HHS K99 LM011392NLM NIH HHS R01 LM009520NLM NIH HHS R01LM009520
6 · The paper itself

Abstract

Prognostic models are increasingly being used in clinical practice. The benefit of adding variables (e.g., gene expression measurements) to an original set of variables (e.g., phenotypes) when building prognostic models is usually measured on a whole set of cases. In practice, however, including additional information only helps build better models for some subsets of cases. It is important to prioritize who should undergo further testing. We present a method that can help identify those patients might benefit from additional testing. Our experiments based on limited breast cancer data indicate that relatively old patients with large tumors and positive lymph nodes constitute a group for whom prognoses can be more accurate with the addition of gene expression measurements. The same is not true for some other groups.

Indexed as

Gene ExpressionArea Under CurveBreast NeoplasmsFemaleGene Expression ProfilingGenotypeHumansLogistic ModelsPhenotypePrognosisTranscriptome

Identifiers

PMID23304404
PMCPMC3540468

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.