Evidence map›Paper›PMID 23304366›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2012

An evaluation of the NQF Quality Data Model for representing Electronic Health Record driven phenotyping algorithms.

William K Thompson, Luke V Rasmussen, Jennifer A Pacheco, Peggy L Peissig, Joshua C Denny, Abel N Kho, Aaron Miller, Jyotishman Pathak

Abstract readEvaluation Study
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. Representation of EHR data for predictive modeling: a comparison between UMLS and other terminologies.Journal of the American Medical Informatics Association : JAMIA · 2020
    Article
  3. Article
  4. Developing a FHIR-based Framework for Phenome Wide Association Studies: A Case Study with A Pan-Cancer Cohort.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2020
    Article
  5. UK phenomics platform for developing and validating electronic health record phenotypes: CALIBER.Journal of the American Medical Informatics Association : JAMIA · 2019
    Article
  6. Article
  7. Facilitating phenotype transfer using a common data model.Journal of biomedical informatics · 2019
    Article
  8. Article
  9. Defining Phenotypes from Clinical Data to Drive Genomic Research.Annual review of biomedical data science · 2018
    Article
  10. Article
  11. Article
  12. PheKB: a catalog and workflow for creating electronic phenotype algorithms for transportability.Journal of the American Medical Informatics Association : JAMIA · 2016
    Article
  13. Article
  14. A Decompositional Approach to Executing Quality Data Model Algorithms on the i2b2 Platform.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2016
    Article
  15. Article
  16. Article
  17. Article
  18. Desiderata for computable representations of electronic health records-driven phenotype algorithms.Journal of the American Medical Informatics Association : JAMIA · 2015
    Article
  19. A Modular Architecture for Electronic Health Record-Driven Phenotyping.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2015
    Article
  20. A Prototype for Executable and Portable Electronic Clinical Quality Measures Using the KNIME Analytics Platform.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

William K ThompsonNorthwestern University, Chicago, IL, USA.
Luke V Rasmussen
Jennifer A Pacheco
Peggy L Peissig
Joshua C Denny
Abel N Kho
Aaron Miller
Jyotishman Pathak

Funding

Genomic Basis of Susceptibility to COVID-19 Infection and its ComplicationsU01HG006379 · NHGRI · MAYO CLINIC ROCHESTER · PI Richard R. Sharp · 2011 to 2026
$16.5M
UC Davis Clinical and Translational Science CenterUL1TR000002 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2012 to 2015
$12.2M
Multidisciplinary Clinical and Translational Science (MCTS) Program (UL1)UL1TR000150 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LLOYD-JONES, DONALD M · 2012 to 2013
$10.1M
Vanderbilt Genome-Electronic Records ProjectU01HG004603 · NHGRI · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2007 to 2011
$7.3M
From GWAS to PheWAS: Scanning the EMR Phenome for Gene-disease AssociationsR01LM010685 · NLM · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BASTARACHE, LISA · 2011 to 2022
$6.3M
A Personalized Genomic Medicine Pilot Program Using the NJgene eMERGE ExperienceU01HG006388 · NHGRI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHISHOLM, REX L, SMITH, MAUREEN E · 2011 to 2014
$4.1M
IRIS: Incorporating Research Into SightU01HG006389 · NHGRI · ESSENTIA INSTITUTE OF RURAL HEALTH · PI MCCARTY, CATHERINE ANNE · 2011 to 2014
$4.1M
Vanderbilt Genome Electronic Records ProjectU01HG006378 · NHGRI · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2011 to 2014
$4.0M
NCATS NIH HHS UL1 TR000002NCATS NIH HHS UL1 TR000150NHGRI NIH HHS 1U01 HG004603NHGRI NIH HHS 1U01 HG006379NHGRI NIH HHS 1U01 HG006388-01NHGRI NIH HHS 1U01 HG006389-01NHGRI NIH HHS U01 HG004603NHGRI NIH HHS U01 HG006378NHGRI NIH HHS U01 HG006379NHGRI NIH HHS U01 HG006388NHGRI NIH HHS U01 HG006389NLM NIH HHS R01 LM010685
6 · The paper itself

Abstract

The development of Electronic Health Record (EHR)-based phenotype selection algorithms is a non-trivial and highly iterative process involving domain experts and informaticians. To make it easier to port algorithms across institutions, it is desirable to represent them using an unambiguous formal specification language. For this purpose we evaluated the recently developed National Quality Forum (NQF) information model designed for EHR-based quality measures: the Quality Data Model (QDM). We selected 9 phenotyping algorithms that had been previously developed as part of the eMERGE consortium and translated them into QDM format. Our study concluded that the QDM contains several core elements that make it a promising format for EHR-driven phenotyping algorithms for clinical research. However, we also found areas in which the QDM could be usefully extended, such as representing information extracted from clinical text, and the ability to handle algorithms that do not consist of Boolean combinations of criteria.

Indexed as

AlgorithmsElectronic Health RecordsPhenotypeBiomedical ResearchHumansNatural Language ProcessingProgramming LanguagesQuality Control

Identifiers

PMID23304366
PMCPMC3540514

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.