ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2012
Evaluation of automated term groupings for detecting anaphylactic shock signals for drugs.
Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Development and validation of a MedDRA-based signal detection construct for drug-induced neurobehavioral impairment.Therapeutic advances in drug safety · 2026Article
- Article
- Ontological and Non-Ontological Resources for Associating Medical Dictionary for Regulatory Activities Terms to SNOMED Clinical Terms With Semantic Properties.Frontiers in pharmacology · 2019Article
- Article
- Good Signal Detection Practices: Evidence from IMI PROTECT.Drug safety · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Signal detection in pharmacovigilance should take into account all terms related to a medical concept rather than a single term. We built an OWL-DL file with formal definitions of MedDRA and SNOMED-CT concepts and performed two queries, Query 1 and 2, to retrieve narrow and broad terms within the Standard MedDRA Query (SMQ) related to 'anaphylactic shock' and the terms from the High Level Term (HLT) grouping related to 'anaphylaxis'. We compared values of the EB05 (EBGM) statistical test for disproportionality with 50 active ingredients randomly selected in the public version of the FDA pharmacovigilance database. Coefficient of correlation was R(2) = 1.00 between Query 1 and HLT; R(2) = 0.98 between Query 1 and SMQ narrow; R(2) = 0.89 between Query 2 and SMQ Narrow+Broad. Generating automated groupings of terms for signal detection is feasible but requires additional efforts in modeling MedDRA terms in order to improve precision and recall of these groupings.
Indexed as
Identifiers
23304363PMC3540466What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.