ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2012
Precision and negative predictive value of links between ClinicalTrials.gov and PubMed.
Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of the processes used to link clinical trial registrations to their published results.Systematic reviews · 2017Pooled it
- Article
- Misreporting of Patient-Relevant and Study Design Elements in Anesthesiology Randomized Controlled Trials: An Observational Study.Medical sciences (Basel, Switzerland) · 2025Observational
- Article
- Evaluating the discoverability of supporting research materials in ClinicalTrials.gov for US federally funded COVID-19 clinical studies.Journal of the Medical Library Association : JMLA · 2024Article
- Linking Cancer Clinical Trials to their Result Publications.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2024Article
- regCOVID: Tracking publications of registered COVID-19 studies.BMC medical research methodology · 2022Article
- A web-based tool for automatically linking clinical trials to their publications.Journal of the American Medical Informatics Association : JAMIA · 2022Article
- regCOVID: Tracking publications of registered COVID-19 studies.Research square · 2021Article
- Automated Identification of Common Disease-Specific Outcomes for Comparative Effectiveness Research Using ClinicalTrials.gov: Algorithm Development and Validation Study.JMIR medical informatics · 2021Article
- Disparities in patient enrollment on glioblastoma clinical trials.CNS oncology · 2020Article
- Linking quality indicators to clinical trials: an automated approach.International journal for quality in health care : journal of the International Society for Quality in Health Care · 2017Article
- Current status and perspectives of interventional clinical trials for glioblastoma - analysis of ClinicalTrials.gov.Radiation oncology (London, England) · 2017Review
- Systematic review protocol assessing the processes for linking clinical trial registries and their published results.BMJ open · 2016Article
- Aggregator: a machine learning approach to identifying MEDLINE articles that derive from the same underlying clinical trial.Methods (San Diego, Calif.) · 2015Article
- Article
- How transparent are migraine clinical trials? Repository of Registered Migraine Trials (RReMiT).Neurology · 2014Article
- Extent of non-publication in cohorts of studies approved by research ethics committees or included in trial registries.PloS one · 2014Article
- Evaluating adherence to the International Committee of Medical Journal Editors' policy of mandatory, timely clinical trial registration.Journal of the American Medical Informatics Association : JAMIA · 2013Article
- Linking ClinicalTrials.gov and PubMed to track results of interventional human clinical trials.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
One of the goals of translational science is to shorten the time from discovery to clinical use. Clinical trial registries were established to increase transparency in completed and ongoing clinical trials, and they support linking trials with resulting publications. We set out to investigate precision and negative predictive value (NPV) of links between ClinicalTrials.gov (CT.gov) and PubMed. CT.gov has been established to increase transparency in clinical trials and the link to PubMed is crucial for supporting a number of important functions, including ascertaining publication bias. We drew a random sample of trials downloaded from CT.gov and performed manual review of retrieved publications. We characterize two types of links between trials and publications (NCT-link originating from MEDLINE and PMID-link originating from CT.gov).The link precision is different based on type (NCT-link: 100%; PMID-link: 63% to 96%). In trials with no linked publication, we were able to find publications 44% of the time (NPV=56%) by searching PubMed. This low NPV shows that there are potentially numerous publications that should have been formally linked with the trials. Our results indicate that existing trial registry and publisher policies may not be fully enforced. We suggest some automated methods for improving link quality.
Indexed as
Identifiers
23304310PMC3540528What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.