Evidence map›Paper›PMID 23304305›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2012

Automated extraction of reported statistical analyses: towards a logical representation of clinical trial literature.

William Hsu, William Speier, Ricky K Taira

Abstract read
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. A Scoping Review of Adopted Information Extraction Methods for RCTs.Medical journal of the Islamic Republic of Iran · 2023
    Article
  7. Article
  8. Improving reference prioritisation with PICO recognition.BMC medical informatics and decision making · 2019
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Evaluating a Novel Summary Visualization for Clinical Trial Reports: A Usability Study.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2016
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

William HsuMedical Imaging Informatics Group, Dept of Radiological Sciences, University of California, Los Angeles, CA, USA.
William Speier
Ricky K Taira

Funding

Toward Individually-tailored Medicine: Probabilistic Models of Cerebral AneurysmsR01EB000362 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BUI, ALEX · 2003 to 2012
$5.1M
Training Program for Imaging Based Medical InformaticsT15LM007356 · NLM · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BUI, ALEX · 2002 to 2011
$5.0M
Data Structuring and Visualization System for Neuro-oncologyR01LM009961 · NLM · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TAIRA, RICKY K. · 2009 to 2010
$1.7M
NIBIB NIH HHS R01 EB000362NLM NIH HHS 5R01LM009961NLM NIH HHS 5T15LM007356NLM NIH HHS R01 LM009961NLM NIH HHS T15 LM007356
6 · The paper itself

Abstract

Randomized controlled trials are an important source of evidence for guiding clinical decisions when treating a patient. However, given the large number of studies and their variability in quality, determining how to summarize reported results and formalize them as part of practice guidelines continues to be a challenge. We have developed a set of information extraction and annotation tools to automate the identification of key information from papers related to the hypothesis, sample size, statistical test, confidence interval, significance level, and conclusions. We adapted the Automated Sequence Annotation Pipeline to map extracted phrases to relevant knowledge sources. We trained and tested our system on a corpus of 42 full-text articles related to chemotherapy of non-small cell lung cancer. On our test set of 7 papers, we obtained an overall precision of 86%, recall of 78%, and an F-score of 0.82 for classifying sentences. This work represents our efforts towards utilizing this information for quality assessment, meta-analysis, and modeling.

Indexed as

Electronic Data ProcessingRandomized Controlled Trials as TopicCarcinoma, Non-Small-Cell LungEvidence-Based MedicineHumansInformation Storage and RetrievalLung NeoplasmsNatural Language ProcessingSensitivity and Specificity

Identifiers

PMID23304305
PMCPMC3540551

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.