ArticleOxidative medicine and cellular longevity2012
Silica nanoparticles sensitize human multiple myeloma cells to snake (Walterinnesia aegyptia) venom-induced apoptosis and growth arrest.
Article in Oxidative medicine and cellular longevity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- Nanobiotechnology with Therapeutically Relevant Macromolecules from Animal Venoms: Venoms, Toxins, and Antimicrobial Peptides.Pharmaceutics · 2022Review
- Venom of the desert black snakeToxicology research · 2021Article
- Molecular mechanisms underlying antitumor activity of camel whey protein against multiple myeloma cells.Saudi journal of biological sciences · 2021Article
- Review
- Camel whey protein enhances lymphocyte survival by modulating the expression of survivin, bim/bax, and cytochrome C and restores heat stress-mediated pathological alteration in lymphoid organs.Iranian journal of basic medical sciences · 2018Article
- Nanoparticle delivery systems, general approaches, and their implementation in multiple myeloma.European journal of haematology · 2017Review
- Camel whey protein improves lymphocyte function and protects against diabetes in the offspring of diabetic mouse dams.International journal of immunopathology and pharmacology · 2016Article
- Silica nanoparticles induce start inhibition of meiosis and cell cycle arrestToxicology research · 2016Article
- Engineered nanomedicine for myeloma and bone microenvironment targeting.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Nonlinear effects of nanoparticles: biological variability from hormetic doses, small particle sizes, and dynamic adaptive interactions.Dose-response : a publication of International Hormesis Society · 2014Article
- Integrative nanomedicine: treating cancer with nanoscale natural products.Global advances in health and medicine · 2014Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple myeloma (MM), an almost incurable disease, is the second most common blood cancer. Initial chemotherapeutic treatment could be successful; however, resistance development urges the use of higher toxic doses accompanied by hematopoietic stem cell transplantation. The establishment of more effective treatments that can overcome or circumvent chemoresistance has become a priority. We recently demonstrated that venom extracted from Walterinnesia aegyptia (WEV) either alone or in combination with silica nanoparticles (WEV+NPs) mediated the growth arrest and apoptosis of prostate cancer cells. In the present study, we evaluated the impact of WEV alone and WEV+NP on proliferation and apoptosis of MM cells.
methodsThe impacts of WEV alone and WEV+NP were monitored in MM cells from 70 diagnosed patients. The influences of WEV and WEV+NP were assessed with flow cytometry analysis.
resultsWEV alone and WEV+NP decreased the viability of MM cells. Using a CFSE proliferation assay, we found that WEV+NP strongly inhibited MM cell proliferation. Furthermore, analysis of the cell cycle using the propidium iodide (PI) staining method indicated that WEV+NP strongly altered the cell cycle of MM cells and enhanced the induction of apoptosis.
conclusionsOur data reveal the biological effects of WEV and WEV+NP on MM cells that enable these compounds to function as effective treatments for MM.
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