ArticleEvidence-based complementary and alternative medicine : eCAM2012
Effects of Extract from Mangifera indica Leaf on Monosodium Urate Crystal-Induced Gouty Arthritis in Rats.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Therapeutic potential and pharmacological mechanisms of Traditional Chinese Medicine in gout treatment.Acta pharmacologica Sinica · 2025Review
- Effect of Mangifera Indica (Mango) on Dental Caries: A Systematic Review.Nutrition and metabolic insights · 2023Review
- Anti-Inflammatory and Antioxidant Properties ofMarine drugs · 2022Article
- Phytochemistry and Diverse Pharmacology of GenusBiomolecules · 2022Review
- A Comprehensive Review of the Ethnotraditional Uses and Biological and Pharmacological Potential of the GenusInternational journal of molecular sciences · 2021Review
- Evaluation of the anti-gout effect ofMedicine and pharmacy reports · 2021Article
- Article
- The Efficacy and Mechanism of Chinese Herbal Medicines in Lowering Serum Uric Acid Levels: A Systematic Review.Frontiers in pharmacology · 2020Article
- Attenuating effects ofVeterinary research forum : an international quarterly journal · 2019Article
- Anti-gout Potential of Malaysian Medicinal Plants.Frontiers in pharmacology · 2018Review
- A Review on Ethnopharmacological Applications, Pharmacological Activities, and Bioactive Compounds ofEvidence-based complementary and alternative medicine : eCAM · 2017Review
- Effects of the Aqueous Extract fromEvidence-based complementary and alternative medicine : eCAM · 2017Article
- Zisheng Shenqi decoction ameliorates monosodium urate crystal-induced gouty arthritis in rats through anti-inflammatory and anti-oxidative effects.Molecular medicine reports · 2016Article
- Therapeutic Effects of Chinese Medicine Herb Pair, Huzhang and Guizhi, on Monosodium Urate Crystal-Induced Gouty Arthritis in Rats Revealed by Anti-Inflammatory Assessments and NMR-Based Metabonomics.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Effects of RuPeng15 Powder (RPP15) on Monosodium Urate Crystal-Induced Gouty Arthritis in Rats.Evidence-based complementary and alternative medicine : eCAM · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The leaves of Mangifera indica L. (Anacardiaceae) is used as a medicinal material in traditional herb medicine for a long time in India, China, and other Eastern Asian countries. Our present study investigated the therapeutic effects of the ethanol extract from Mangifera indica (EMI) in rat with monosodium urate (MSU) crystals-induced gouty arthritis. Effects of EMI (50, 100, and 200 mg/kg, p.o.) administrated for 9 days on the ankle swelling, synovial tumor necrosis factor-alpha (TNF-α), and interleukin-1beta (IL-1β) levels were assessed in MSU crystal rat. Data from our study showed that rat with gouty arthritis induced by MSU crystal demonstrated an elevation in ankle swelling, synovial TNF-α, IL-1β mRNA, and protein levels. Oral administration of 100 and 200 mg/kg EMI for 9 days reversed the abnormalities in ankle swelling, synovial TNF-α, IL-1β mRNA, and protein levels. The results indicated that the beneficial antigouty arthritis effect of EMI may be mediated, at least in part, by inhibiting TNF-α and IL-1β expression in the synovial tissues. Our study suggests that Mangifera indica and its extract may have a considerable potential for development as an anti-gouty arthritis agent for clinical application.
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Registered trials
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