ArticleDose-response : a publication of International Hormesis Society2012
Hemopoietic response to low dose-rates of ionizing radiation shows stem cell tolerance and adaptation.
Article in Dose-response : a publication of International Hormesis Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Molecular and cellular basis of the dose-rate-dependent adverse effects of radiation exposure in animal models. Part II: Hematopoietic system, lung and liver.Journal of radiation research · 2023Review
- Article
- Radiation dose rate effects: what is new and what is needed?Radiation and environmental biophysics · 2022Review
- Effects of Chronic Low-Dose Internal Radiation on Immune-Stimulatory Responses in Mice.International journal of molecular sciences · 2021Article
- Low-dose ionizing radiation as a hormetin: experimental observations and therapeutic perspective for age-related disorders.Biogerontology · 2021Review
- Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study.Environmental health and preventive medicine · 2021Article
- PHA stimulation may be useful for FDXR gene expression-based biodosimetry.Iranian journal of basic medical sciences · 2020Article
- DNA damage response in peripheral mouse blood leukocytes in vivo after variable, low-dose rate exposure.Radiation and environmental biophysics · 2020Article
- Bone Marrow and Peripheral Blood Cells Toxicity of a Single 2.0 Gy CobaltEthiopian journal of health sciences · 2019Article
- Remedy for radiation fear - discard the politicized science.Dose-response : a publication of International Hormesis Society · 2014Article
- Low dose radiation adaptive protection to control neurodegenerative diseases.Dose-response : a publication of International Hormesis Society · 2014Article
- Commentary on fukushima and beneficial effects of low radiation.Dose-response : a publication of International Hormesis Society · 2013Article
- Special issue introduction.Dose-response : a publication of International Hormesis Society · 2012Article
- Treatment of Alzheimer Disease With CT Scans: A Case Report.Dose-response : a publication of International Hormesis SocietyArticle
- Cancer Mortality Among People Living in Areas With Various Levels of Natural Background Radiation.Dose-response : a publication of International Hormesis SocietyArticle
- Treatment of Early-Stage Alzheimer's Disease With CT Scans of the Brain: A Case Report.Dose-response : a publication of International Hormesis SocietyArticle
- Evidence That Lifelong Low Dose Rates of Ionizing Radiation Increase Lifespan in Long- and Short-Lived Dogs.Dose-response : a publication of International Hormesis SocietyArticle
- Application of Low Doses of Ionizing Radiation in Medical Therapies.Dose-response : a publication of International Hormesis SocietyArticle
- Evidence of a Dose Threshold for Radiation-Induced Leukemia.Dose-response : a publication of International Hormesis SocietyArticle
- The Double Threshold: Consequences for Identifying Low-Dose Radiation Effects.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic exposure of mammals to low dose-rates of ionizing radiation affects proliferating cell systems as a function of both dose-rate and the total dose accumulated. The lower the dose-rate the higher needs to be the total dose for a deterministic effect, i.e., tissue reaction to appear. Stem cells provide for proliferating, maturing and functional cells. Stem cells usually are particularly radiosensitive and damage to them may propagate to cause failure of functional cells. The paper revisits 1) medical histories with emphasis on the hemopoietic system of the victims of ten accidental chronic radiation exposures, 2) published hematological findings of long-term chronically gamma-irradiated rodents, and 3) such findings in dogs chronically exposed in large life-span studies. The data are consistent with the hypothesis that hemopoietic stem and early progenitor cells have the capacity to tolerate and adapt to being repetitively hit by energy deposition events. The data are compatible with the "injured stem cell hypothesis", stating that radiation-injured stem cells, depending on dose-rate, may continue to deliver clones of functional cells that maintain homeostasis of hemopoiesis throughout life. Further studies perhaps on separated hemopoietic stem cells may unravel the molecular-biology mechanisms causing radiation tolerance and adaptation.
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