ArticleDose-response : a publication of International Hormesis Society2012
Small γ-Ray Doses Prevent Rather than Increase Lung Tumors in Mice.
Article in Dose-response : a publication of International Hormesis Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Mechanistic Effects of Environmental and Medical Low-Dose Radiation Exposure of the Lung.Biomedicines · 2026Review
- Repetitive exposure to low-dose X-irradiation attenuates testicular apoptosis in type 2 diabetic rats, likely via Akt-mediated Nrf2 activation.Molecular and cellular endocrinology · 2016Article
- Special issue introduction.Dose-response : a publication of International Hormesis Society · 2012Article
- Low-dose gamma-radiation inhibits benzo[a]pyrene-induced lung adenoma development in a/j mice.Dose-response : a publication of International Hormesis Society · 2012Article
- Role of ATP as a Key Signaling Molecule Mediating Radiation-Induced Biological Effects.Dose-response : a publication of International Hormesis SocietyArticle
- Radiophobia Harm, Its Main Cause, and a Proposed Solution.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We show evidence for low doses of γ rays preventing spontaneous hyperplastic foci and adenomas in the lungs of mice, presumably via activating natural anticancer defenses. The evidence partly relates to a new study we conducted whereby a small number of female A/J mice received 6 biweekly dose fractions (100 mGy per fraction) of γ rays to the total body which prevented the occurrence of spontaneous hyperplastic foci in the lung. We also analyzed data from a much earlier Oak Ridge National Laboratory study involving more than 10,000 female RFMf/Un mice whereby single γ-ray doses from 100 to 1,000 mGy prevented spontaneous lung adenomas. We point out the possibility that the decrease in lung cancer mortality observed in The National Lung Screening Trial Research Team study involving lung tumor screening using low-dose computed tomography (CT) may relate at least in part to low-dose X-rays activating the body's natural anticancer defenses (i.e., radiation hormesis). This possibility was apparently not recognized by the indicated research team.
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Registered trials
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