ArticleDose-response : a publication of International Hormesis Society2012
Low-dose gamma-radiation inhibits benzo[a]pyrene-induced lung adenoma development in a/j mice.
Article in Dose-response : a publication of International Hormesis Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Mechanistic Effects of Environmental and Medical Low-Dose Radiation Exposure of the Lung.Biomedicines · 2026Review
- Radiation dose rate effects: what is new and what is needed?Radiation and environmental biophysics · 2022Review
- Adaptive responses to low doses of radiation or chemicals: their cellular and molecular mechanisms.Cellular and molecular life sciences : CMLS · 2019Review
- Cancer immunotherapy: how low-level ionizing radiation can play a key role.Cancer immunology, immunotherapy : CII · 2017Review
- Radiation-hormesis phenotypes, the related mechanisms and implications for disease prevention and therapy.Journal of cell communication and signaling · 2014Article
- Special issue introduction.Dose-response : a publication of International Hormesis Society · 2012Article
- Small γ-Ray Doses Prevent Rather than Increase Lung Tumors in Mice.Dose-response : a publication of International Hormesis Society · 2012Article
- Radiophobia Harm, Its Main Cause, and a Proposed Solution.Dose-response : a publication of International Hormesis SocietyArticle
- A Breakthrough on Modeling Cancer Prevention and Elimination by Low Radiation Doses.Dose-response : a publication of International Hormesis SocietyArticle
- Late Effects of Low-Dose Radiation on the Bone Marrow, Lung, and Testis Collected From the Same Exposed BALB/cJ Mice.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low-dose ionizing radiation (LDR) may lead to suppression of smoking-related lung cancer. We examined the effects of a known cigarette smoke carcinogen Benzo[a]pyrene (B[a]P) alone or in combination with fractionated low-dose gamma radiation (60 - 600 mGy total dose) on the induction of lung neoplasms in the A/J mouse. Our results show that 600 mGy of gamma radiation delivered in six biweekly fractions of 100 mGy starting 1 month after B[a]P injection significantly inhibits the development of lung adenomas per animal induced by B[a]P. Our data also indicated that the six biweekly doses suppressed the occurrence of spontaneous hyperplastic foci in the lung, although this suppression failed to reach statistical significance when analyzed as average foci per lung possibly related to the small sample sizes used for the control and test groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.