ReviewArchaea (Vancouver, B.C.)2012
Phylogenomic investigation of phospholipid synthesis in archaea.
Review in Archaea (Vancouver, B.C.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Characterization of aliA and aliB deletion mutants reveals a dominant role of AliA in Haloferax volcanii lipoprotein lipidation.The Journal of biological chemistry · 2026Article
- Harnessing evolution: leveraging bacterial isoprenoid pathway diversity toward improved bioengineering strategies.Journal of bacteriology · 2026Review
- Uncovering the prevalence, key biogenesis enzymes, and biological significance of archaeal lipoproteins.Nature communications · 2025Article
- Identification of acetylated diether lipids in halophilic Archaea.MicrobiologyOpen · 2022Article
- Fatty Acid Synthase: Structure, Function, and Regulation.Sub-cellular biochemistry · 2022Review
- Bridging the membrane lipid divide: bacteria of the FCB group superphylum have the potential to synthesize archaeal ether lipids.The ISME journal · 2021Article
- Functionalized Membrane Domains: An Ancestral Feature of Archaea?Frontiers in microbiology · 2020Article
- Investigating the Origins of Membrane Phospholipid Biosynthesis Genes Using Outgroup-Free Rooting.Genome biology and evolution · 2019Article
- Biosynthesis, regulation, and engineering of microbially produced branched biofuels.Biotechnology for biofuels · 2019Review
- Structural and mechanistic insights into the biosynthesis of CDP-archaeol in membranes.Cell research · 2017Article
- Characterization of feedback-resistant mevalonate kinases from the methanogenic archaeons Methanosaeta concilii and Methanocella paludicola.Microbiology (Reading, England) · 2017Article
- Identification and Characterization of Heptaprenylglyceryl Phosphate Processing Enzymes in Bacillus subtilis.The Journal of biological chemistry · 2016Article
- Article
- Structure and Evolution of the Archaeal Lipid Synthesis Enzyme sn-Glycerol-1-phosphate Dehydrogenase.The Journal of biological chemistry · 2015Article
- Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering.Molecular bioSystems · 2015Review
- Liquid but durable: molecular dynamics simulations explain the unique properties of archaeal-like membranes.Scientific reports · 2014Article
- A re-evaluation of the archaeal membrane lipid biosynthetic pathway.Nature reviews. Microbiology · 2014Review
- From promiscuity to the lipid divide: on the evolution of distinct membranes in Archaea and Bacteria.Journal of molecular evolution · 2014Article
- Phylogenomic reconstruction of archaeal fatty acid metabolism.Environmental microbiology · 2014Article
- The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life.Natural product reports · 2014Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Archaea have idiosyncratic cell membranes usually based on phospholipids containing glycerol-1-phosphate linked by ether bonds to isoprenoid lateral chains. Since these phospholipids strongly differ from those of bacteria and eukaryotes, the origin of the archaeal membranes (and by extension, of all cellular membranes) was enigmatic and called for accurate evolutionary studies. In this paper we review some recent phylogenomic studies that have revealed a modified mevalonate pathway for the synthesis of isoprenoid precursors in archaea and suggested that this domain uses an atypical pathway of synthesis of fatty acids devoid of any acyl carrier protein, which is essential for this activity in bacteria and eukaryotes. In addition, we show new or updated phylogenetic analyses of enzymes likely responsible for the isoprenoid chain synthesis from their precursors and the phospholipid synthesis from glycerol phosphate, isoprenoids, and polar head groups. These results support that most of these enzymes can be traced back to the last archaeal common ancestor and, in many cases, even to the last common ancestor of all living organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.