ArticleTransactions of the American Clinical and Climatological Association2012
A tale of mice and (wo)men: development of and insights from an "all human" animal model of breast cancer metastasis to bone.
Article in Transactions of the American Clinical and Climatological Association, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Methods for culturing human femur tissue explants to study breast cancer cell colonization of the metastatic niche.Journal of visualized experiments : JoVE · 2015Article
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Authors and funding
1 author.
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Abstract
There are 200,000 new cases of breast cancer (BrCa) annually in the United States. Metastasis to bone signals a life-threatening phase of this disease. Little progress has been made in understanding the pathogenesis of metastasis. Few validated drug targets have been identified. So there is a compelling need to understand the molecular mechanisms by which BrCa metastasizes to bone (osteotropism). There is need for animal models that reflect the complex biology of metastasis in humans. We performed research designed to elucidate the mechanisms of osteotropism from both sides of the tumor-stroma interface. We created an "all human" model in which human bone is transplanted into non-obese diabetic/severe combined immunodeficient immunodeficient (NOD/SCID) mice. Human BrCa cells injected into the mammary fat pad later metastasize to bone. We also found traffic in the opposite direction: bone marrow stem cells migrate from human bone to human breast tumors in the mouse. We are identifying osteotropism genes used by BrCa to metastasize to human bone.
Indexed as
Identifiers
23303981PMC3540630What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.