ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Medial prefrontal cortex inversely regulates toluene-induced changes in markers of synaptic plasticity of mesolimbic dopamine neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Toluene alters the intrinsic excitability and excitatory synaptic transmission of basolateral amygdala neurons.Frontiers in neuroscience · 2024Article
- The Effects of the Inhalant Toluene on Cognitive Function and Behavioral Flexibility: A Review of Recent Findings.Addiction neuroscience · 2023Article
- A brief exposure to toluene vapor alters the intrinsic excitability of D2 medium spiny neurons in the rat ventral striatum.Frontiers in neuroscience · 2023Article
- α2δ-1 protein drives opioid-induced conditioned reward and synaptic NMDA receptor hyperactivity in the nucleus accumbens.Journal of neurochemistry · 2023Article
- Modulating the Neuromodulators: Dopamine, Serotonin, and the Endocannabinoid System.Trends in neurosciences · 2021Review
- Self-Administration of Toluene Vapor in Rats.Frontiers in neuroscience · 2020Article
- Viral vector strategies for investigating midbrain dopamine circuits underlying motivated behaviors.Pharmacology, biochemistry, and behavior · 2018Review
- Exposure to the Abused Inhalant Toluene Alters Medial Prefrontal Cortex Physiology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Chemogenetic Excitation of Accumbens-Projecting Infralimbic Cortical Neurons Blocks Toluene-Induced Conditioned Place Preference.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Persistent cognitive and morphological alterations induced by repeated exposure of adolescent rats to the abused inhalant toluene.Neurobiology of learning and memory · 2017Article
- The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens Dopamine D1 Receptor Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Temporal profiles dissociate regional extracellular ethanol versus dopamine concentrations.ACS chemical neuroscience · 2015Article
- Specific impairments in instrumental learning following chronic intermittent toluene inhalation in adolescent rats.Psychopharmacology · 2014Article
- Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking.Nature neuroscience · 2014Article
- Pharmacological classification of the abuse-related discriminative stimulus effects of trichloroethylene vapor.Journal of drug and alcohol research · 2014Article
- Reward and aversion in a heterogeneous midbrain dopamine system.Neuropharmacology · 2014Review
- Review of toluene action: clinical evidence, animal studies and molecular targets.Journal of drug and alcohol research · 2014Article
- Effects of the abused inhalant toluene on the mesolimbic dopamine system.Journal of drug and alcohol research · 2014Article
- GABAA receptor drugs and neuronal plasticity in reward and aversion: focus on the ventral tegmental area.Frontiers in pharmacology · 2014Article
- Volatile solvents as drugs of abuse: focus on the cortico-mesolimbic circuitry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Toluene is a volatile solvent that is intentionally inhaled by children, adolescents, and adults for its intoxicating effects. Although voluntary use of toluene suggests that it possesses rewarding properties and abuse potential, it is unknown whether toluene alters excitatory synaptic transmission in reward-sensitive dopamine neurons like other drugs of abuse. Here, using a combination of retrograde labeling and slice electrophysiology, we show that a brief in vivo exposure of rats to a behaviorally relevant concentration of toluene vapor enhances glutamatergic synaptic strength of dopamine (DA) neurons projecting to nucleus accumbens core and medial shell neurons. This effect persisted for up to 3 d in mesoaccumbens core DA neurons and for at least 21 d in those projecting to the medial shell. In contrast, toluene vapor exposure had no effect on synaptic strength of DA neurons that project to the medial prefrontal cortex (mPFC). Furthermore, infusion of GABAergic modulators into the mPFC before vapor exposure to pharmacologically manipulate output, inhibited, or potentiated toluene's action on mesoaccumbens DA neurons. Together, the results of these studies indicate that toluene induces a target-selective increase in mesolimbic DA neuron synaptic transmission and strongly implicates the mPFC as an important regulator of drug-induced plasticity of mesolimbic dopamine neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.