Evidence map›Paper›PMID 23303905›Full record

ReviewPhysiological reviews2013

Satellite cells and the muscle stem cell niche.

Hang Yin, Feodor Price, Michael A Rudnicki

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Physiological reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05671614 (Skeletal Muscle Regeneration in Survivors of Critical Illness), which is not on this map. Cited by 1,208 papers.

0numbers the graph read from it
0cells of the map it votes in
1,208citing papers in PubMed
51.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05671614 recruitingnot on this mapstarted 2022, after this paper: background citation

Skeletal Muscle Regeneration in Survivors of Critical Illness: How to Prevent Satellite Cell Failure?

TypeobservationalSponsorCharles University, Czech RepublicRan2022 to 2025Enrolled50ConditionsIntensive Care Unit-acquired Weakness
3 · Its place in the literature

Who cites it

1,208 citing papers in PubMed, 2,128 citations in OpenAlex.

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1,148 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Hang YinRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Feodor Price
Michael A Rudnicki
Ottawa Hospital Research InstituteOttawa Hospital · CA

Funding

GENETIC REGULATION OF SKELETAL MUSCLE REPAIRR01AR044031 · NIAMS · OTTAWA HOSPITAL RESEARCH INSTITUTE · PI RUDNICKI, MICHAEL A · 1996 to 2025
$5.6M
NIAMS NIH HHS R01 AR044031
6 · The paper itself

Abstract

Adult skeletal muscle in mammals is a stable tissue under normal circumstances but has remarkable ability to repair after injury. Skeletal muscle regeneration is a highly orchestrated process involving the activation of various cellular and molecular responses. As skeletal muscle stem cells, satellite cells play an indispensible role in this process. The self-renewing proliferation of satellite cells not only maintains the stem cell population but also provides numerous myogenic cells, which proliferate, differentiate, fuse, and lead to new myofiber formation and reconstitution of a functional contractile apparatus. The complex behavior of satellite cells during skeletal muscle regeneration is tightly regulated through the dynamic interplay between intrinsic factors within satellite cells and extrinsic factors constituting the muscle stem cell niche/microenvironment. For the last half century, the advance of molecular biology, cell biology, and genetics has greatly improved our understanding of skeletal muscle biology. Here, we review some recent advances, with focuses on functions of satellite cells and their niche during the process of skeletal muscle regeneration.

Indexed as

Muscle DevelopmentRegenerationStem Cell NicheAdult Stem CellsAnimalsBiomarkersCell DifferentiationCell ProliferationGene Expression RegulationHumansMuscle, SkeletalMuscular DiseasesSatellite Cells, Skeletal MuscleBiomarkers

Identifiers

PMID23303905
PMCPMC4073943
OpenAlexW2017075649

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.