ArticleNucleic acids research2013
Space exploration by the promoter of a long human gene during one transcription cycle.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- RNA polymerase II transcription compartments - from factories to condensates.Nature reviews. Genetics · 2025Review
- Transcription regulates the spatio-temporal dynamics of genes through micro-compartmentalization.Nature communications · 2024Article
- Deep-learning microscopy image reconstruction with quality control reveals second-scale rearrangements in RNA polymerase II clusters.PNAS nexus · 2022Article
- Coordination of transcription, processing, and export of highly expressed RNAs by distinct biomolecular condensates.Emerging topics in life sciences · 2020Article
- Review
- Large distances separate coregulated genes in livingProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Transcription-driven genome organization: a model for chromosome structure and the regulation of gene expression tested through simulations.Nucleic acids research · 2018Review
- Higher-Order Chromatin Regulation of Inflammatory Gene Expression.Mediators of inflammation · 2017Review
- Chromatin architecture underpinning transcription elongation.Nucleus (Austin, Tex.) · 2016Review
- Super-resolution measurement of distance between transcription sites using RNA FISH with intronic probes.Methods (San Diego, Calif.) · 2016Article
- Review
- Spatial Organization of Epigenomes.Current molecular biology reports · 2016Article
- Splicing of many human genes involves sites embedded within introns.Nucleic acids research · 2015Article
- The Role of Crowding Forces in Juxtaposing β-Globin Gene Domain Remote Regulatory Elements in Mouse Erythroid Cells.PloS one · 2015Article
- The dynamic architectural and epigenetic nuclear landscape: developing the genomic almanac of biology and disease.Journal of cellular physiology · 2014Review
- Models that include supercoiling of topological domains reproduce several known features of interphase chromosomes.Nucleic acids research · 2014Article
- Super-resolution molecular and functional imaging of nanoscale architectures in life and materials science.Frontiers in bioengineering and biotechnology · 2014Review
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
An RNA polymerase has been thought to transcribe by seeking out a promoter, initiating and then tracking down the template. We add tumor necrosis factor α to primary human cells, switch on transcription of a 221-kb gene and monitor promoter position during the ensuing transcription cycle (using RNA fluorescence in situ hybridization coupled to super-resolution localization, chromosome conformation capture and Monte Carlo simulations). Results are consistent with a polymerase immobilized in a 'factory' capturing a promoter and reeling in the template, as the transcript and promoter are extruded. Initially, the extruded promoter is tethered close to the factory and so likely to re-initiate; later, the tether becomes long enough to allow re-initiation in another factory. We suggest close tethering underlies enhancer function and transcriptional 'bursting'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.