ArticleDevelopmental neurobiology2013
Embryonic origins of the mouse superior olivary complex.
Article in Developmental neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Inverse expression of Ten3 and Lphn2 across the developing mouse brain suggests a global strategy for circuit assembly.Current biology : CB · 2026Article
- Developmental patterns of extracellular matrix molecules in the embryonic and postnatal mouse hindbrain.Frontiers in neuroanatomy · 2024Article
- Comparative expression analysis of the Atoh7 gene regulatory network in the mouse and chicken auditory hindbrain.Cell and tissue research · 2023Article
- Long-term microglia depletion impairs synapse elimination and auditory brainstem function.Scientific reports · 2022Article
- Molecular Organization and Patterning of the Medulla Oblongata in Health and Disease.International journal of molecular sciences · 2022Review
- Age-Related Hearing Loss: Sensory and Neural Etiology and Their Interdependence.Frontiers in aging neuroscience · 2022Review
- Neurosensory development of the four brainstem-projecting sensory systems and their integration in the telencephalon.Frontiers in neural circuits · 2022Article
- The Untouchable Ventral Nucleus of the Trapezoid Body: Preservation of a Nucleus in an Animal Model of Autism Spectrum Disorder.Frontiers in integrative neuroscience · 2021Article
- Article
- Glial Cell Expansion Coincides with Neural Circuit Formation in the Developing Auditory Brainstem.Developmental neurobiology · 2018Article
- Talking back: Development of the olivocochlear efferent system.Wiley interdisciplinary reviews. Developmental biology · 2018Review
- The role of the Rx homeobox gene in retinal progenitor proliferation and cell fate specification.Mechanisms of development · 2018Article
- Nuclear derivatives and axonal projections originating from rhombomere 4 in the mouse hindbrain.Brain structure & function · 2017Article
- Cellular and Molecular Underpinnings of Neuronal Assembly in the Central Auditory System during Mouse Development.Frontiers in neural circuits · 2017Review
- En1 is necessary for survival of neurons in the ventral nuclei of the lateral lemniscus.Developmental neurobiology · 2016Article
- Reconstitution of Giant Mammalian Synapses in Culture for Molecular Functional and Imaging Studies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Functional Role of γ-Crystallin N in the Auditory Hindbrain.PloS one · 2016Article
- En1 directs superior olivary complex neuron positioning, survival, and expression of FoxP1.Developmental biology · 2015Article
- The gene regulatory networks underlying formation of the auditory hindbrain.Cellular and molecular life sciences : CMLS · 2015Review
- Sound localization ability and glycinergic innervation of the superior olivary complex persist after genetic deletion of the medial nucleus of the trapezoid body.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Many areas of the central nervous system are organized into clusters of cell groups, with component cell groups exhibiting diverse but related functions. One such cluster, the superior olivary complex (SOC), is located in the ventral auditory brainstem in mammals. The SOC is an obligatory contact point for most projection neurons of the ventral cochlear nucleus and plays central roles in many aspects of monaural and binaural information processing. Despite their important interrelated functions, little is known about the embryonic origins of SOC nuclei, due in part to a paucity of developmental markers to distinguish individual cell groups. In this report, we present a collection of novel markers for the developing SOC nuclei in mice, including the transcription factors FoxP1, MafB, and Sox2, and the lineage-marking transgenic line En1-Cre. We use these definitive markers to examine the rhombic lip and rhombomeric origins of SOC nuclei and demonstrate that they can serve to uniquely identify SOC nuclei and subnuclei in newborn pups. The markers are also useful in identifying distinct nuclear domains within the presumptive SOC as early as embryonic day (E) 14.5, well before morphological distinction of individual nuclei is evident. These findings indicate that the mediolateral and dorsoventral position of SOC nuclei characteristic of the adult brainstem is established during early neurogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.