ArticleJournal of clinical microbiology2013
Differences and similarities between culture-confirmed human granulocytic anaplasmosis and early lyme disease.
Article in Journal of clinical microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Utility of combined detection of IgG/IgM/IgA vs. separate IgG and IgM antibodies to Anaplasma phagocytophilum in culture and PCR-confirmed patients with human granulocytic anaplasmosis.Wiener klinische Wochenschrift · 2026Article
- Tick-borne anaplasmosis and myocarditis in eastern Ontario.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Article
- Antibodies to Anaplasma phagocytophilum in Patients with Human Granulocytic Anaplasmosis Confirmed by Both Polymerase Chain Reaction and Culture.The American journal of medicine · 2025Article
- Culture and other direct detection methods to diagnose human granulocytic anaplasmosis.American journal of clinical pathology · 2025Article
- A sex-based analysis of complete blood count features during acute, untreated Lyme disease.Frontiers in medicine · 2024Article
- Tick-Borne Co-Infections: Challenges in Molecular and Serologic Diagnoses.Pathogens (Basel, Switzerland) · 2023Review
- Capture Sequencing Enables Sensitive Detection of Tick-Borne Agents in Human Blood.Frontiers in microbiology · 2022Article
- Laboratory Diagnosis of Lyme Borreliosis.Clinical microbiology reviews · 2021Review
- Differences in clinicopathologic variables between Borrelia C6 antigen seroreactive and Borrelia C6 seronegative glomerulopathy in dogs.Journal of veterinary internal medicine · 2019Article
- Value of PCR, Serology, and Blood Smears for Human Granulocytic Anaplasmosis Diagnosis, France.Emerging infectious diseases · 2019Article
- Management approaches for suspected and established Lyme disease used at the Lyme disease diagnostic center.Wiener klinische Wochenschrift · 2018Article
- Smear Campaign: Misattribution of Pancytopenia to a Tick-Borne Illness.Journal of general internal medicine · 2018Article
- Fatigue in patients with erythema migrans.Diagnostic microbiology and infectious disease · 2016Article
- Accuracy of Diagnosis of Human Granulocytic Anaplasmosis in China.Emerging infectious diseases · 2016Article
- Review
- Human granulocytic anaplasmosis.Infectious disease clinics of North America · 2015Review
- Sensitive multiplex PCR assay to differentiate Lyme spirochetes and emerging pathogens Anaplasma phagocytophilum and Babesia microti.BMC microbiology · 2013Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lyme disease is transmitted by the bite of certain Ixodes ticks, which can also transmit Anaplasma phagocytophilum, the cause of human granulocytic anaplasmosis (HGA). Although culture can be used to identify patients infected with A. phagocytophilum and is the microbiologic gold standard, few studies have evaluated culture-confirmed patients with HGA. We conducted a prospective study in which blood culture was used to detect HGA infection in patients with a compatible clinical illness. Early Lyme disease was defined by the presence of erythema migrans. The epidemiologic, clinical, and laboratory features of 44 patients with culture-confirmed HGA were compared with those of a convenience sample of 62 patients with early Lyme disease. Coinfected patients were excluded. Patients with HGA had more symptoms (P = 0.003) and had a higher body temperature on presentation (P < 0.001) than patients with early Lyme disease. HGA patients were also more likely to have a headache, dizziness, myalgias, abdominal pain, anorexia, leukopenia, lymphopenia, thrombocytopenia, or elevated liver enzymes. A direct correlation between the number of symptoms and the duration of illness at time of presentation (rho = 0.389, P = 0.009) was observed for HGA patients but not for patients with Lyme disease. In conclusion, although there are overlapping features, culture-confirmed HGA is a more severe illness than early Lyme disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.