ArticleOpen biology2013
Regulation of neurite growth by tumour necrosis superfamily member RANKL.
Article in Open biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Review
- Osteoclast-derived extracellular vesicles are implicated in sensory neurons sprouting through the activation of epidermal growth factor signaling.Cell & bioscience · 2022Article
- How CD40L reverse signaling regulates axon and dendrite growth.Cellular and molecular life sciences : CMLS · 2021Article
- Tumor necrosis factor alpha mediates neuromuscular synapse elimination.Cell discovery · 2020Article
- CD40L reverse signaling suppresses prevertebral sympathetic axon growth and tissue innervation.Developmental neurobiology · 2019Article
- CD40 forward signalling is a physiological regulator of early sensory axon growth.Development (Cambridge, England) · 2019Article
- Regional Differences in the Contributions of TNF Reverse and Forward Signaling to the Establishment of Sympathetic Innervation.Developmental neurobiology · 2019Article
- TWE-PRIL reverse signalling suppresses sympathetic axon growth and tissue innervation.Development (Cambridge, England) · 2018Article
- Control of neurite growth and guidance by an inhibitory cell-body signal.PLoS computational biology · 2018Article
- TNF superfamily member APRIL enhances midbrain dopaminergic axon growth and contributes to the nigrostriatal projection in vivo.Experimental neurology · 2017Article
- CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons.eLife · 2017Article
- Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation.Neural development · 2016Article
- Tumor Necrosis Factor-α Underlies Loss of Cortical Dendritic Spine Density in a Mouse Model of Congestive Heart Failure.Journal of the American Heart Association · 2015Article
- Regulation of Autocrine Signaling in Subsets of Sympathetic Neurons Has Regional Effects on Tissue Innervation.Cell reports · 2015Article
- Emerging roles of gut microbiota and the immune system in the development of the enteric nervous system.The Journal of clinical investigation · 2015Review
- Modular and coordinated expression of immune system regulatory and signaling components in the developing and adult nervous system.Frontiers in cellular neuroscience · 2015Article
- A Neurologist's Guide to TNF Biology and to the Principles behind the Therapeutic Removal of Excess TNF in Disease.Neural plasticity · 2015Review
- Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL.Molecular and cellular neurosciences · 2014Article
- TNFα reverse signaling promotes sympathetic axon growth and target innervation.Nature neuroscience · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
RANKL (receptor-activator of NF-κB ligand, TNFSF11) is a member of the TNF superfamily that regulates bone remodelling and the development of the thymus, lymph nodes and mammary glands. While RANKL and its membrane bound receptor RANK (TNFRSF11A) are expressed in the adult central nervous system and have been implicated in thermoregulation, the potential function of RANK signalling in the developing nervous system remains unexplored. Here, we show that RANK is expressed by sympathetic and sensory neurons of the developing mouse peripheral nervous system and that activating RANK signalling in these neurons during perinatal development by either treating cultured neurons with soluble RANKL or overexpressing RANK in the neurons inhibited neurotrophin-promoted neurite growth without affecting neurotrophin-promoted neuronal survival. RANKL is expressed in tissues innervated by these neurons, and studies in compartment cultures demonstrated that RANKL is capable of acting directly on neurites to inhibit growth locally. Enhancing RANK signalling in cultured neurons resulted in NF-κB activation and phosphorylation of the p65 NF-κB subunit on serine 536. Transfecting neurons with a series of mutated signalling proteins showed that NF-κB activation and p65 phosphorylation occurred by an IKKβ-dependent mechanism and that blockade of this signalling pathway prevented neurite growth inhibition by RANKL. These findings reveal that RANKL is a novel negative regulator of neurite growth from developing PNS neurons and that it exerts its effects by IKKβ-dependent activation of NF-κB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.