ArticleGenes and immunity2013
miR-31 regulates interleukin 2 and kinase suppressor of ras 2 during T cell activation.
Article in Genes and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Review
- Non-coding RNAs: Key players in T cell exhaustion.Frontiers in immunology · 2022Review
- The Role of microRNAs in the Mammary Gland Development, Health, and Function of Cattle, Goats, and Sheep.Non-coding RNA · 2021Review
- Identification of candidate miRNA biomarkers for facioscapulohumeral muscular dystrophy using DUX4-based mouse models.Disease models & mechanisms · 2021Article
- Mycoplasma hyopneumoniae J elicits an antioxidant response and decreases the expression of ciliary genes in infected swine epithelial cells.Scientific reports · 2020Article
- MicroRNA 31 inhibits CD8Cellular & molecular immunology · 2018Article
- Control of Immunoregulatory Molecules by miRNAs in T Cell Activation.Frontiers in immunology · 2018Review
- The microRNA miR-31 inhibits CD8Nature immunology · 2017Article
- Host Genetic Background Strongly Affects Pulmonary microRNA Expression before and during Influenza A Virus Infection.Frontiers in immunology · 2017Article
- Article
- The role of microRNA-31 and microRNA-21 as regulatory biomarkers in the activation of T lymphocytes of Egyptian lupus patients.Rheumatology international · 2016Article
- Function and regulation of microRNA-31 in development and disease.Molecular reproduction and development · 2016Review
- Effect of tumor necrosis factor-α induced protein 8 like-2 on immune function of dendritic cells in mice following acute insults.Oncotarget · 2016Article
- Characteristics of TCRζ, ZAP-70, and FcɛRIγ gene expression in patients with T- and NK/T-cell lymphoma.DNA and cell biology · 2015Article
- ARG-walker: inference of individual specific strengths of meiotic recombination hotspots by population genomics analysis.BMC genomics · 2015Article
- miR-20a inhibits TCR-mediated signaling and cytokine production in human naïve CD4+ T cells.PloS one · 2015Article
- Review
- MicroRNA Regulation in Systemic Lupus Erythematosus Pathogenesis.Immune network · 2014Review
- microRNAs and the mammary gland: A new understanding of gene expression.Genetics and molecular biology · 2013Review
- From cell biology to immunology: Controlling metastatic progression of cancer via microRNA regulatory networks.OncoimmunologyReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNA (miRNA) has an important role as a master regulator of gene expression in immune system and is upregulated during T cell differentiation, however its function is not clear yet. In this study, the contribution of miR-31 in T cell activation was investigated. miR-31 was upregulated during the activation of primary T lymphocytes upon T-cell receptor (TCR) stimulation. Ectopic expression of miR-31 increased the expression of interleukin (IL)-2, while knockdown of endogenous miR-31 decreased the IL-2 expression. To gain more insights into the regulatory mechanism, we performed a bioinformatic analysis and found miR-31 potentially targeted kinase suppressor of ras 2 (KSR2), a repression factor of Ras2 kinase. Using reporter gene and western blotting assays, we confirmed that miR-31 could inhibit KSR2 by directly targeting its 3' untranslated region (UTR). Moreover, miR-31 enhanced nuclear factor of activated T cells (NF-AT) activity in Jurkat T cells, and increased transcription activity of IL-2 promoter in primary T cells. In conclusion, our study demonstrated that miR-31 upregulated IL-2 expression via reduction of its up-stream kinase suppressor, KSR2, and is a component of T cell activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.