ArticleThe Pediatric infectious disease journal2013
Resistance in pediatric patients experiencing virologic failure with first-line and second-line antiretroviral therapy.
Article in The Pediatric infectious disease journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Contribution of Gag and Protease to HIV-1 Phenotypic Drug Resistance in Pediatric Patients Failing Protease Inhibitor-Based Therapy.Antimicrobial agents and chemotherapy · 2016Trial
- Article
- Outcomes After Second-Line Antiretroviral Therapy in Children Living With HIV in Latin America.Journal of acquired immune deficiency syndromes (1999) · 2021Article
- Cost-Effectiveness of Preemptive Switching to Efavirenz-Based Antiretroviral Therapy for Children With Human Immunodeficiency Virus.Open forum infectious diseases · 2019Article
- Article
- High rates of virological failure and drug resistance in perinatally HIV-1-infected children and adolescents receiving lifelong antiretroviral therapy in routine clinics in Togo.Journal of the International AIDS Society · 2016Article
- Genetic Changes in HIV-1 Gag-Protease Associated with Protease Inhibitor-Based Therapy Failure in Pediatric Patients.AIDS research and human retroviruses · 2015Article
- Cost-effectiveness of first-line antiretroviral therapy for HIV-infected African children less than 3 years of age.AIDS (London, England) · 2015Article
- Explaining antiretroviral therapy adherence success among HIV-infected children in rural Uganda: a qualitative study.AIDS and behavior · 2015Article
- Assessment of HIV antiretroviral therapy adherence by measuring drug concentrations in hair among children in rural Uganda.AIDS care · 2015Observational
- Drug resistance in children at virological failure in a rural KwaZulu-Natal, South Africa, cohort.AIDS research and therapy · 2014Article
- High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen.PloS one · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We examined HIV-1 resistance in children failing first-line and second-line antiretroviral therapy in South Africa, all with clade C virus. Those exposed to full-dose ritonavir had multiple protease resistance mutations. Nineteen percent had wild-type virus. Appropriate antiretroviral therapy sequencing in sub-Saharan African children is essential for prolong treatment options.
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Registered trials
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