ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013
White matter abnormalities in skin picking disorder: a diffusion tensor imaging study.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Double-Blind, Placebo-Controlled Study of Memantine in Body Focused Repetitive Behaviors
A Double-Blind, Placebo Controlled Study of Aripiprazole in Body Focused Repetitive Behaviors
Who cites it
25 citing papers in PubMed, 80 citations in OpenAlex.
- Morphometric brain MRI findings in hair-pulling and skin-picking disorders in youth.Psychiatry research. Neuroimaging · 2025Article
- Atypical cerebellar activity and connectivity during affective touch in adults with skin-picking disorder.Brain imaging and behavior · 2024Article
- Obsessive-compulsive disorder: Etiology, neuropathology, and cognitive dysfunction.Brain and behavior · 2023Review
- Neurobiology of subtypes of trichotillomania and skin picking disorder.CNS spectrums · 2023Article
- Negative Affectivity Moderates the Relationship between Attentional Control and Focused Skin Picking.International journal of environmental research and public health · 2022Article
- Reward processing in trichotillomania and skin picking disorder.Brain imaging and behavior · 2022Article
- Skin picking disorder: Does a person's sex matter?Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists · 2022Article
- Case Report: NovelFrontiers in neurology · 2022Article
- rTMS investigation of resistant Obsessive-Compulsive Related Disorders: Efficacy of targeting the reward system.Frontiers in psychiatry · 2022Article
- Diagnosis and Treatment of Obsessive-Compulsive and Related Disorders.Focus (American Psychiatric Publishing) · 2021Article
- Trichotillomania and Skin-Picking Disorder: An Update.Focus (American Psychiatric Publishing) · 2021Article
- Dermatillomania: Strategies for Developing Protective Biomaterials/Cloth.Pharmaceutics · 2021Review
- Resting-State Functional Connectivity of Supplementary Motor Area Associated with Skin-Picking Symptom Severity.Journal of obsessive-compulsive and related disorders · 2020Article
- The Role of the Cerebellum in Skin-Picking Disorder.Cerebellum (London, England) · 2019Article
- Visual symptom provocation in skin picking disorder: an fMRI study.Brain imaging and behavior · 2018Article
- Neuronal responses to the scratching and caressing of one's own skin in patients with skin-picking disorder.Human brain mapping · 2018Article
- Neuroanatomical Correlates of Impulsive Action in Excoriation (Skin-Picking) Disorder.The Journal of neuropsychiatry and clinical neurosciences · 2018Article
- Neurocognitive Findings in Onychophagia (Pathological Nail Biting).The Psychiatric quarterly · 2017Article
- A structural MRI study of excoriation (skin-picking) disorder and its relationship to clinical severity.Psychiatry research. Neuroimaging · 2017Article
- Does comorbidity matter in body-focused repetitive behavior disorders?Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin picking disorder (SPD) is characterized by the repetitive and compulsive picking of skin, resulting in tissue damage. Neurocognitive findings in SPD implicate difficulty with response inhibition (suppression of pre-potent motor responses). This function is dependent on the integrity of the right frontal gyrus and the anterior cingulate cortices, and white-matter tracts connecting such neural nodes. It was hypothesized that SPD would be associated with reduced fractional anisotropy in regions implicated in top-down response suppression, particularly white-matter tracts in proximity of the bilateral anterior cingulate and right frontal (especially orbitofrontal and inferior frontal) cortices. 13-subjects meeting proposed SPD criteria for DSM-5 free from other current psychiatric comorbidities, and 12 healthy comparison subjects underwent MRI with a 3-T system. Between-group comparisons of imaging data underwent voxelwise analysis with permutation modeling and cluster correction. Fractional anisotropy (measured using diffusion tensor imaging) was the primary outcome measure. Subjects with SPD exhibited significantly reduced fractional anisotropy in tracts distributed bilaterally, which included the anterior cingulate cortices. Fractional anisotropy did not correlate significantly with SPD disease severity, or depressive or anxiety scores. These findings implicate disorganization of white-matter tracts involved in motor generation and suppression in the pathophysiology of SPD, findings remarkably similar to those previously reported in trichotillomania. This study adds considerable support to the notion that-in addition to the phenomenological and comorbid overlap between SPD and trichotillomania-these disorders likely share overlapping neurobiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.