Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013
Serotonin 2A receptors, citalopram and tryptophan-depletion: a multimodal imaging study of their interactions during response inhibition.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Selection and stopping in voluntary action: a meta-analysis and combined fMRI study.NeuroImage · 2014Pooled it
- Predicting beneficial effects of atomoxetine and citalopram on response inhibition in Parkinson's disease with clinical and neuroimaging measures.Human brain mapping · 2016Trial
- Improving response inhibition systems in frontotemporal dementia with citalopram.Brain : a journal of neurology · 2015Trial
- Improving response inhibition in Parkinson's disease with atomoxetine.Biological psychiatry · 2015Trial
- Attentional control and interpretation of facial expression after oxytocin administration to typically developed male adults.PloS one · 2015Trial
- The relationship between reward and punishment processing and the 5-HT1A receptor as shown by PET.Psychopharmacology · 2014Trial
- Selective serotonin reuptake inhibition modulates response inhibition in Parkinson's disease.Brain : a journal of neurology · 2014Trial
- Serotonergic dysfunction in patients with impulse control disorders in Parkinson's disease.Brain : a journal of neurology · 2025Article
- Direct serotonin release in humans shapes aversive learning and inhibition.Nature communications · 2024Article
- Use of experimental medicine approaches for the development of novel psychiatric treatments based on orexin receptor modulation.Neuroscience and biobehavioral reviews · 2023Review
- Which came first: Cannabis use or deficits in impulse control?Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- Atomoxetine and citalopram alter brain network organization in Parkinson's disease.Brain communications · 2019Article
- Childhood Adversity Moderates the Effects ofFrontiers in psychiatry · 2019Article
- Dissociable effects of acute SSRI (escitalopram) on executive, learning and emotional functions in healthy humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- The neurobiology of impulse control disorders in Parkinson's disease: from neurotransmitters to neural networks.Cell and tissue research · 2018Review
- Neurotransmitter deficits from frontotemporal lobar degeneration.Brain : a journal of neurology · 2018Review
- Cortical and Striatal Reward Processing in Parkinson's Disease Psychosis.Frontiers in neurology · 2017Article
- An Update on the Role of Serotonin and its Interplay with Dopamine for Reward.Frontiers in human neuroscience · 2017Review
- Auditory evoked potential could reflect emotional sensitivity and impulsivity.Scientific reports · 2016Article
- Effect of Pharmacological Interventions on the Fronto-Cingulo-Parietal Cognitive Control Network in Psychiatric Disorders: A Transdiagnostic Systematic Review of fMRI Studies.Frontiers in psychiatry · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
Poor behavioral inhibition is a common feature of neurological and psychiatric disorders. Successful inhibition of a prepotent response in 'NoGo' paradigms requires the integrity of both the inferior frontal gyrus (IFG) and the serotonergic system. We investigated individual differences in serotonergic regulation of response inhibition. In 24 healthy adults, we used (18)F-altanserin positron emission tomography to assess cerebral 5-HT2A receptors, which have been related to impulsivity. We then investigated the impact of two acute manipulations of brain serotonin levels on behavioral and neural correlates of inhibition using intravenous citalopram and acute tryptophan depletion during functional magnetic resonance imaging. We adapted the NoGo paradigm to isolate effects on inhibition per se as opposed to other aspects of the NoGo paradigm. Successful NoGo inhibition was associated with greater activation of the right IFG compared to control trials with alternative responses, indicating that the IFG is activated with inhibition in NoGo trials rather than other aspects of invoked cognitive control. Activation of the left IFG during NoGo trials was greater with citalopram than acute tryptophan depletion. Moreover, with the NoGo-type of response inhibition, the right IFG displayed an interaction between the type of serotonergic challenge and neocortical 5-HT2A receptor binding. Specifically, acute tryptophan depletion (ATD) produced a relatively larger NoGo response in the right IFG in subjects with low 5-HT2A BPP but reduced the NoGo response in those with high 5-HT2A BPP. These links between serotonergic function and response inhibition in healthy subjects may help to interpret serotonergic abnormalities underlying impulsivity in neuropsychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.