ArticleVirulence2013
Galleria mellonella as a model host to study Paracoccidioides lutzii and Histoplasma capsulatum.
Article in Virulence, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Serological evidence of paracoccidioidomycosis infection in pantanal caimans (Caiman yacare).Veterinary research communications · 2026Article
- Review
- Paracoccidioides lutzii Infects Galleria mellonella Employing Formamidase as a Virulence Factor.PLoS neglected tropical diseases · 2024Article
- Article
- Social life of free-living amoebae in aquatic environment- comprehensive insights into interactions of free-living amoebae with neighboring microorganisms.Frontiers in microbiology · 2024Review
- Role of paracoccin onVirulence · 2023Article
- Article
- Alternative Non-Mammalian Animal and Cellular Methods for the Study of Host-Fungal Interactions.Journal of fungi (Basel, Switzerland) · 2023Review
- Article
- On the relationship between Pathogenic Potential and Infective Inoculum.PLoS pathogens · 2022Article
- War of the microbial world: Acanthamoeba spp. interactions with microorganisms.Folia microbiologica · 2021Review
- Fungal α-1,3-Glucan as a New Pathogen-Associated Molecular Pattern in the Insect Model HostMolecules (Basel, Switzerland) · 2021Article
- Virulence of ClinicalPathogens (Basel, Switzerland) · 2021Article
- Fungal immunity and pathogenesis in mammals versus the invertebrate model organism Galleria mellonella.Pathogens and disease · 2021Review
- Silver(I) and Copper(II) Complexes of 1,10-Phenanthroline-5,6-Dione AgainstFrontiers in microbiology · 2021Article
- Overview of Antifungal Drugs against Paracoccidioidomycosis: How Do We Start, Where Are We, and Where Are We Going?Journal of fungi (Basel, Switzerland) · 2020Review
- In Vitro or In Vivo Models, the Next Frontier for Unraveling Interactions betweenJournal of fungi (Basel, Switzerland) · 2020Review
- Rearing and Maintenance ofJournal of fungi (Basel, Switzerland) · 2020Review
- Proteomic analysis of the processes leading to Madurella mycetomatis grain formation in Galleria mellonella larvae.PLoS neglected tropical diseases · 2020Article
- Caenorhabditis elegans as a model animal for investigating fungal pathogenesis.Medical microbiology and immunology · 2020Review
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Authors and funding
6 authors.
Funding
Abstract
Non-mammalian models have been used to investigate fungal virulence. In this work we have explored the use of Galleria mellonella as an infection model for the pathogenic dimorphic fungi Histoplasma capsulatum and Paracoccidioides lutzii. In mammalian models these fungi cause similar infections, and disease outcomes are influenced by the quantity of the infective inocula. We describe a similar aspect in a G. mellonella model and characterize the pathogenesis features in this system. Infection with P. lutzii or H. capsulatum, in all inoculum used, killed larvae at 25 and 37°C. However, there was a lack of correlation between the number of yeast cells used for infection and the time to larvae death, which may indicate that the fungi induce protective responses in a dynamic manner as the lowest concentrations of fungi induced the most rapid death. For both fungi, the degree of larvae melanization was directly proportional to the inocula size, and this effect was visibly more apparent at 37°C. Histological evaluation of the larvae showed a correlation between the inoculum and granuloma-like formation. Our results suggest that G. mellonella is a potentially useful model to study virulence of dimorphic fungi.
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