ArticleJournal of translational medicine2013
Clinical analysis of selected complement-derived molecules in human adipose tissue.
Article in Journal of translational medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Psychopathology and Stem Cell Mobilization in Ultra-High Risk of Psychosis and First-Episode Psychosis Patients.International journal of environmental research and public health · 2022Article
- Complement activation in obesity, insulin resistance, and type 2 diabetes mellitus.World journal of diabetes · 2020Review
- Culturing Articular Cartilage Explants in the Presence of Autologous Adipose Tissue Modifies Their Inflammatory Response to Lipopolysaccharide.Mediators of inflammation · 2020Article
- Whole genome mRNA expression profiling revealed multiple deregulated pathways in stromal vascular fraction from erectile dysfunction patients.Bioscience reports · 2018Article
- Targeting viperin improves diet-induced glucose intolerance but not adipose tissue inflammation.Oncotarget · 2017Article
- Mobilization of Peripheral Blood Stem Cells and Changes in the Concentration of Plasma Factors Influencing their Movement in Patients with Panic Disorder.Stem cell reviews and reports · 2017Article
- The role of complement system in adipose tissue-related inflammation.Immunologic research · 2016Review
- Complement Component 3 Is Associated with Metabolic Comorbidities in Older HIV-Positive Adults.AIDS research and human retroviruses · 2016Observational
- An Attempt to Evaluate Selected Aspects of "Bone-Fat Axis" Function in Healthy Individuals and Patients With Pancreatic Cancer.Medicine · 2015Article
- Adipokines: a link between obesity and dementia?The Lancet. Neurology · 2014Review
- LPS response pattern of inflammatory adipokines in an in vitro 3T3-L1 murine adipocyte model.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2014Article
- Association of immune and metabolic receptors C5aR and C5L2 with adiposity in women.Mediators of inflammation · 2014Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has been suggested that action of complement cascade [CC]-derived anaphylatoxins/molecules may represent a missing link between obesity and metabolic disorders. However, to date, the direct biochemical/immunomodulatory composition of the human AT environment remains poorly understood. In this study, we examined plasma and AT (subcutaneous and visceral/omental) levels of selected CC-derived anaphylatoxins/molecules, and adipsin as well as verified their associations with immune and stem cells chemoattractant - stromal-derived factor-1 (SDF-1).
methodsA total of 70 (35 subcutaneous and 35 omental) AT samples were obtained from patients undergoing elective surgery. Plasma and AT-derived interstitial fluid levels of C3a, C5a, C5b-9/membrane attack complex (MAC), complement factor D (adipsin) were measured using ELISA.
resultsAT levels of all examined substances were significantly lower than the corresponding levels in the plasma (in all cases P < 0.0000001). Moreover, in subcutaneous AT, robust C3a and adipsin concentrations were observed, whereas high levels of C5b-9/MAC were detected in the visceral depots. In addition, we established the correlations between analyzed molecular substances and body composition, BMI and/or the adiposity index of the examined patients.
conclusionsOur study demonstrated for the first time that significantly reduced levels of complement-derived molecules were present in human AT than in the peripheral blood, and that these factors are associated with the metabolic status of examined individuals. Moreover, in human AT, various associations between complement-derived molecules and SDF-1 levels exist.
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