ArticleJournal of natural products2013
Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445).
Article in Journal of natural products, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- TheMolecules (Basel, Switzerland) · 2026Article
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- Microorganism-Derived Molecules as Enzyme Inhibitors to Target Alzheimer's Diseases Pathways.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Fungi as mutualistic partners in ant-plant interactions.Frontiers in fungal biology · 2023Review
- Discovery ofMarine drugs · 2022Article
- Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity.Natural products and bioprospecting · 2021Article
- Article
- qNMR for profiling the production of fungal secondary metabolites.Magnetic resonance in chemistry : MRC · 2017Article
- Biosynthesis of Fluorinated Peptaibols Using a Site-Directed Building Block Incorporation Approach.Journal of natural products · 2017Article
- Prealamethicin F50 and related peptaibols fromRSC advances · 2017Article
- Chemoinformatic expedition of the chemical space of fungal products.Future medicinal chemistry · 2016Article
- Talarolutins A-D: Meroterpenoids from an endophytic fungal isolate of Talaromyces minioluteus.Phytochemistry · 2016Article
- Spiroscytalin, a new tetramic acid and other metabolites of mixed biogenesis from Scytalidium cuboideum.Tetrahedron · 2015Article
- New diketopiperazine dimer from a filamentous fungal isolate of Aspergillus sydowii.Magnetic resonance in chemistry : MRC · 2015Article
- Sorbicillinoid analogs with cytotoxic and selective anti-Aspergillus activities from Scytalidium album.The Journal of antibiotics · 2015Article
- Comparison of the chemistry and diversity of endophytes isolated from wild-harvested and greenhouse-cultivated yerba mansa (Phytochemistry letters · 2015Article
- Biosynthetically Distinct Cytotoxic Polyketides fromEuropean journal of organic chemistry · 2015Article
- Greensporones: resorcylic acid lactones from an aquatic Halenospora sp.Journal of natural products · 2014Article
- Polyhydroxyanthraquinones as quorum sensing inhibitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry.Journal of natural products · 2014Article
- Genome-guided discovery of diverse natural products from Burkholderia sp.Journal of industrial microbiology & biotechnology · 2014Review
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Authors and funding
10 authors.
Funding
Abstract
Three bioactive compounds were isolated from an organic extract of an ascomycete fungus of the order Chaetothyriales (MSX 47445) using bioactivity-directed fractionation as part of a search for anticancer leads from filamentous fungi. Of these, two were benzoquinones [betulinan A (1) and betulinan C (3)], and the third was a terphenyl compound, BTH-II0204-207:A (2). The structures were elucidated using a set of spectroscopic and spectrometric techniques; the structure of the new compound (3) was confirmed via single-crystal X-ray diffraction. Compounds 1-3 were evaluated for cytotoxicity against a human cancer cell panel, for antimicrobial activity against Staphylococcus aureus and Candida albicans, and for phosphodiesterase (PDE4B2) inhibitory activities. The putative binding mode of 1-3 with PDE4B2 was examined using a validated docking protocol, and the binding and enzyme inhibitory activities were correlated.
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