ArticleAnnals of laboratory medicine2013
Point of care D-dimer testing in the emergency department: a bioequivalence study.
Article in Annals of laboratory medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Preliminary comparative evaluation of an immunofluorescence point-of-care system and central laboratory platforms for measuring cardiac biomarkers.Practical laboratory medicine · 2026Article
- Thromboelastometry and D-Dimer Elevation in Coronavirus-2019.Journal of cardiothoracic and vascular anesthesia · 2020Article
- D-dimer testing for safe exclusion and risk stratification in patients with acute pulmonary embolism in primary care.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Article
- Point-of-care testing in the overcrowded emergency department--can it make a difference?Critical care (London, England) · 2014Article
- Fluorescence immunoassay of human D-dimer in whole blood.Journal of clinical laboratory analysis · 2014Article
- Comments on point of care D-dimer testing in the emergency department: a bioequivalence study.Annals of laboratory medicine · 2014Article
- Evaluation of the usefulness of a D dimer test in combination with clinical pretest probability score in the prediction and exclusion of Venous Thromboembolism by medical residents.Thrombosis journal · 2014Article
- Response to the comments on 'point of care D-dimer testing in the emergency department--a bioequivalence study' and erratum to the results.Annals of laboratory medicine · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundD-dimer is used widely as a diagnostic aid in low- and moderate-risk patients with suspected venous thromboembolism (VTE). While our laboratory utilizes VIDAS D-dimer analyzer (bioMérieux SA, France), our emergency department (ED) recently procured a D-dimer analyzer AQT90 FLEX (Radiometer Medical ApS, Denmark) for point of care testing (POCT) to facilitate patient management. We aimed to determine whether the time taken to receive D-dimer results using the 2 different analyzers differed significantly and to quantify the limits of agreement between the results of the 2 methods measured on the same patient.
methodsAdult patients presenting to the ED and requiring diagnostic workup for suspected VTE were included in this prospective observational study. Patients underwent simultaneous D-dimer measurements using the 2 different analyzers.
resultsThe paired results from 104 patients were analyzed. The median time for the D-dimer results from triage by VIDAS was 258 min (Inter-quartile range [IQR], 173-360) and by POCT was 146 min (IQR, 55-280.5); the median time difference was 101.5 min (IQR, 82-125.5). On an average, POCT D-dimer values were 15% lower on the same sample (limits of agreement, 34-213%). POCT predicted 83% of VIDAS positive results (sensitivity, 83.3% [95% confidence interval (CI), 70.4-91.3%]; specificity, 100% [95% CI, 93.6-100%]). All patients with positive imaging were identified correctly by both methods.
conclusionsPOCT delivers D-dimer results in significantly shorter turnaround times than pathology services; however, poor bioequivalence between VIDAS and POCT raises the issue of acceptability for use in the ED.
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