ArticlePloS one2013
Apathy and white matter integrity in Alzheimer's disease: a whole brain analysis with tract-based spatial statistics.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Apathy, effort-based decisions and brain integrity in Alzheimer's and Parkinson's diseases.Brain : a journal of neurology · 2026Article
- Multimodal Neuroimaging Mechanisms of Apathy in Alzheimer's Disease: A Narrative Review of Structural, Functional, and Molecular Evidence.International journal of general medicine · 2026Review
- Fractional Anisotropy of Cingulum Cingulate Mediates the Relationship Between Happiness and Work Performance in Healthy Individuals.Brain and behavior · 2025Article
- The clinical and neuropsychological profiles of Alzheimer's disease with white matter hyperintensity in North China.Frontiers in neurology · 2024Article
- Cingulate white matter mediates the effects of fecal Ruminococcus on neuropsychiatric symptoms in patients with amyloid-positive amnestic mild cognitive impairment.BMC geriatrics · 2023Article
- An Update on Apathy in Alzheimer's Disease.Geriatrics (Basel, Switzerland) · 2023Review
- Decreased myelin proteins in brain donors exposed to football-related repetitive head impacts.Brain communications · 2023Article
- The neurobiology of apathy in depression and neurocognitive impairment in older adults: a review of epidemiological, clinical, neuropsychological and biological research.Translational psychiatry · 2022Review
- Macrostructural and Microstructural White Matter Alterations Are Associated with Apathy across the Clinical Alzheimer's Disease Spectrum.Brain sciences · 2022Article
- Apathy in small vessel cerebrovascular disease is associated with deficits in effort-based decision making.Brain : a journal of neurology · 2021Article
- Apathy and risk of probable incident dementia among community-dwelling older adults.Neurology · 2020Article
- The Relationship Between Retinal Nerve Fiber Layer Thickness and Clinical Symptoms of Alzheimer's Disease.Frontiers in aging neuroscience · 2020Article
- White matter hyperintensities and neuropsychiatric symptoms in mild cognitive impairment and Alzheimer's disease.NeuroImage. Clinical · 2020Article
- Apathy is associated with large-scale white matter network disruption in small vessel disease.Neurology · 2019Article
- Tau-induced focal neurotoxicity and network disruption related to apathy in Alzheimer's disease.Journal of neurology, neurosurgery, and psychiatry · 2018Article
- Apathy in Alzheimer's disease.Current opinion in behavioral sciences · 2018Review
- Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis.Behavioural neurology · 2018Article
- Comparison of neuropsychiatric symptoms and diffusion tensor imaging correlates among patients with subcortical ischemic vascular disease and Alzheimer's disease.BMC neurology · 2017Article
- Regional 18F-Fluorodeoxyglucose Hypometabolism is Associated with Higher Apathy Scores Over Time in Early Alzheimer Disease.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017Article
- Apathy and intrinsic functional connectivity networks in amnestic mild cognitive impairment.Neuropsychiatric disease and treatment · 2017Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the microstructural alterations of white matter (WM) in Alzheimer's disease (AD) patients with apathy and to observe the relationships with the severity of apathy. Sixty drug-naïve subjects took part in this study (30 apathetic and 30 nonapathetic subjects with AD). The loss of integrity in WM was compared in AD patients with and without apathy through measurement of fractional anisotropy (FA) using by tract-based spatial statistics (TBSS). In addition, we explored the correlation pattern between FA values and the severity of apathy in AD patients with apathy. The apathy group had significantly reduced FA values (p(corrected)<0.05) in the genu of the corpus callosum compared to the nonapathy group. The severity of apathy was negatively correlated with FA values of the left anterior and posterior cingulum, right superior longitudinal fasciculus, splenium, body and genu of the corpus callosum and bilateral uncinate fasciculusin the apathy group (p(corrected)<0.05). This study was the first to explore FA values in whole brain WM in AD patients with apathy. The findings of these microstructural alterations of WM may be the key to the understanding of underlying neurobiological mechanism and clinical significances of apathy in AD.
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