Evidence map›Paper›PMID 23301031›Full record

Trial reportPloS one2013

Psychomotor function in chronic daily Cannabis smokers during sustained abstinence.

Wendy M Bosker, Erin L Karschner, Dayong Lee, Robert S Goodwin, Jussi Hirvonen, Robert B Innis, Eef L Theunissen, Kim P C Kuypers, Marilyn A Huestis, Johannes G Ramaekers

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Intoxication due to Δ9-tetrahydrocannabinol is characterized by disrupted prefrontal cortex activity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Trial
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2021
    Article
  15. Review
  16. Article
  17. Impaired driving and legalization of recreational cannabis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2021
    Article
  18. Review
  19. Article
  20. A Judicial Perspective on Expert Testimony in Marijuana Driving Cases.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Wendy M BoskerDepartment of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The Netherlands.
Erin L Karschner
Dayong Lee
Robert S Goodwin
Jussi Hirvonen
Robert B Innis
Eef L Theunissen
Kim P C Kuypers
Marilyn A Huestis
Johannes G Ramaekers
Maastricht University · NLNational Institute on Drug Abuse · USNational Institute of Mental Health · US

Funding

Clinical Evaluation of PET RadiotracersZIAMH002852 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$48.6M
Pharmacokinetics And Pharmacodynamics Of Smoked Drugs Of AbuseZIADA000413 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI SCHEIDWEILER, KARL · 2009 to 2016
$6.0M
Clinical Evaluation of PET RadiotracersZ01MH002852 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2005 to 2008
$4.4M
Smoked Drugs Of Abuse: Pharmacokinetics/PharmacodynamicsZ01DA000413 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI HUESTIS, MARILYN A · 1998 to 2008
$746k
Intramural NIH HHS Z01 DA000413Intramural NIH HHS Z01 MH002852NIDA NIH HHS Z01-DA000413-13NIMH NIH HHS Z01-MH-002852- 04
6 · The paper itself

Abstract

backgroundThe present study assessed psychomotor function in chronic, daily cannabis smokers during 3 weeks continuously monitored abstinence on a secure research unit. We hypothesized that psychomotor performance would improve during abstinence of chronic, daily cannabis smokers. METHODOLOGY/PRINCIPAL

findingsPerformance on the critical tracking (CTT) and divided attention (DAT) tasks was assessed in 19 male chronic, daily cannabis smokers at baseline and after 8, 14-16 and 21-23 days of continuously monitored abstinence. Psychomotor performance was compared to a control group of non-intoxicated occasional drug users. Critical frequency (λ(c)) of the CTT and tracking error and control losses of the DAT were the primary outcome measures. Results showed that chronic cannabis smokers' performance on the CTT (p<0.001) and the DAT (p<0.001) was impaired during baseline relative to the comparison group. Psychomotor performance in the chronic cannabis smokers improved over 3 weeks of abstinence, but did not recover to equivalent control group performance. CONCLUSIONS/SIGNIFICANCE: Sustained cannabis abstinence moderately improved critical tracking and divided attention performance in chronic, daily cannabis smokers, but impairment was still observable compared to controls after 3 weeks of abstinence. Between group differences, however, need to be interpreted with caution as chronic smokers and controls were not matched for education, social economic status, life style and race.

Indexed as

AdultAttentionCannabisCase-Control StudiesCognitionDronabinolFemaleHumansMaleMarijuana AbuseMarijuana SmokingPsychomotor PerformanceReproducibility of ResultsTime FactorsYoung AdultDronabinol

Identifiers

PMID23301031
PMCPMC3534640
OpenAlexW2131050942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.