ArticlePloS one2012
The mitochondrial fission adaptors Caf4 and Mdv1 are not functionally equivalent.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Mitochondrial fission - changing perspectives for future progress.Journal of cell science · 2025Review
- Review
- Convergent and divergent mechanisms of peroxisomal and mitochondrial division.The Journal of cell biology · 2023Article
- Quantitative Characterisation of Low Abundant Yeast Mitochondrial Proteins Reveals Compensation for Haplo-Insufficiency in Different Environments.International journal of molecular sciences · 2022Article
- Mff oligomerization is required for Drp1 activation and synergy with actin filaments during mitochondrial division.Molecular biology of the cell · 2021Article
- Therapeutic potential and recent advances on targeting mitochondrial dynamics in cardiac hypertrophy: A concise review.Molecular therapy. Nucleic acids · 2021Review
- Peroxisomal fission is induced during appressorium formation and is required for full virulence of the rice blast fungus.Molecular plant pathology · 2017Article
- Dynamin-like proteins in Trypanosoma brucei: A division of labour between two paralogs?PloS one · 2017Article
- Membrane fission by dynamin: what we know and what we need to know.The EMBO journal · 2016Review
- A Targeted Mutation Identified through pKa Measurements Indicates a Postrecruitment Role for Fis1 in Yeast Mitochondrial Fission.The Journal of biological chemistry · 2016Article
- Novel roles for actin in mitochondrial fission.Journal of cell science · 2014Article
- The dual role of cyclin C connects stress regulated gene expression to mitochondrial dynamics.Microbial cell (Graz, Austria) · 2014Review
- Dynamin assembly strategies and adaptor proteins in mitochondrial fission.Current biology : CB · 2013Review
- Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Roles of mitochondrial dynamics under stressful and normal conditions in yeast cells.Oxidative medicine and cellular longevity · 2013Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Mitochondrial fission in eukaryotes is mediated by protein complexes that encircle and divide mitochondrial tubules. In budding yeast, fission requires the membrane-anchored protein Fis1 and the dynamin-related GTPase Dnm1. Dnm1 is recruited to mitochondria via interactions with the adaptor proteins Caf4 and Mdv1, which bind directly to Fis1. Unlike Mdv1, a function for Caf4 in mitochondrial membrane scission has not been established. In this study, we demonstrate that Caf4 is a bona fide fission adaptor that assembles at sites of mitochondrial division. We also show that fission complexes may contain Caf4 alone or both Caf4 and Mdv1 without compromising fission function. Although there is a correspondence between Caf4 and Mdv1 expression levels and their contribution to fission, the two adaptor proteins are not equivalent. Rather, our functional and phylogenetic analyses indicate that Caf4 mitochondrial fission activity has diverged from that of Mdv1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.