ArticlePloS one2012
Multiploid CD61+ cells are the pre-dominant cell lineage infected during acute dengue virus infection in bone marrow.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- P2Y12-P-selectin-mediated platelet activation in a murine model of dengue-associated thrombocytopenia.EBioMedicine · 2026Article
- Evidence that dengue virus envelope protein in patient platelets originates from infection of megakaryocytic precursors.PloS one · 2026Article
- Megakaryocytic Differentiation Regulates the Permissiveness and Antiviral Response of the Megakaryocytic Erythroid Progenitor to Dengue Virus.International journal of molecular sciences · 2025Article
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- Severe dengue in the intensive care unit.Journal of intensive medicine · 2024Review
- Megakaryocytes respond during sepsis and display innate immune cell behaviors.Frontiers in immunology · 2023Article
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- Who did I lie to that day? Deception impairs memory in daily life.Psychological research · 2022Article
- Replication of Dengue Virus in K562-Megakaryocytes Induces Suppression in the Accumulation of Reactive Oxygen Species.Frontiers in microbiology · 2021Article
- Dengue Virus Dysregulates Master Transcription Factors and PI3K/AKT/mTOR Signaling Pathway in Megakaryocytes.Frontiers in cellular and infection microbiology · 2021Article
- From Classical to Unconventional: The Immune Receptors Facilitating Platelet Responses to Infection and Inflammation.Biology · 2020Review
- Crosstalk Between Platelets and Microbial Pathogens.Frontiers in immunology · 2020Review
- Dengue viruses infect human megakaryocytes, with probable clinical consequences.PLoS neglected tropical diseases · 2019Article
- Human megakaryocytes possess intrinsic antiviral immunity through regulated induction of IFITM3.Blood · 2019Article
- Selective Tropism of Dengue Virus for Human Glycoprotein Ib.Scientific reports · 2018Article
- Platelets in Immune Response to Virus and Immunopathology of Viral Infections.Frontiers in medicine · 2018Review
- Article
- Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue.PLoS pathogens · 2017Article
- Microbe-Induced Inflammatory Signals Triggering Acquired Bone Marrow Failure Syndromes.Frontiers in immunology · 2017Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Depression of the peripheral blood platelet count during acute infection is a hallmark of dengue. This thrombocytopenia has been attributed, in part, to an insufficient level of platelet production by megakaryocytes that reside in the bone marrow (BM). Interestingly, it was observed that dengue patients experience BM suppression at the onset of fever. However, few studies focus on the interaction between dengue virus (DENV) and megakaryocytes and how this interaction can lead to a reduction in platelets. In the studies reported herein, BM cells from normal healthy rhesus monkeys (RM) and humans were utilized to identify the cell lineage(s) that were capable of supporting virus infection and replication. A number of techniques were employed in efforts to address this issue. These included the use of viral RNA quantification, nonstructural protein and infectivity assays, phenotypic studies utilizing immunohistochemical staining, anti-differentiation DEAB treatment, and electron microscopy. Cumulative results from these studies revealed that cells in the BM were indeed highly permissive for DENV infection, with human BM having higher levels of viral production compared to RM. DENV-like particles were predominantly observed in multi-nucleated cells that expressed CD61+. These data suggest that megakaryocytes are likely the predominant cell type infected by DENV in BM, which provides one explanation for the thrombocytopenia and the dysfunctional platelets characteristic of dengue virus infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.