ArticlePloS one2012
Maternally administered sustained-release naltrexone in rats affects offspring neurochemistry and behaviour in adulthood.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- The Safety of Alcohol Pharmacotherapies in Pregnancy: A Scoping Review of Human and Animal Research.CNS drugs · 2025Article
- MPharmacology research & perspectives · 2022Article
- Pharmacotherapies for the Treatment of Alcohol Use Disorders During Pregnancy: Time to Reconsider?Drugs · 2021Review
- Cocaine and amphetamine regulated transcript (CART) signalling in the central nucleus of the amygdala modulates stress-induced alcohol seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Acetylcholine Muscarinic MBiological psychiatry · 2020Article
- Anterior Insular Cortex is Critical for the Propensity to Relapse Following Punishment-Imposed Abstinence of Alcohol Seeking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Role of Dopamine 2 Receptor in Impaired Drug-Cue Extinction in Adolescent Rats.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- The metabotropic glutamate 5 receptor is necessary for extinction of cocaine-associated cues.British journal of pharmacology · 2016Article
- Developmental consequences of fetal exposure to drugs: what we know and what we still must learn.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Review
- Caring for Pregnant Women with Opioid Use Disorder in the USA: Expanding and Improving Treatment.Current obstetrics and gynecology reportsReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Naltrexone is not recommended during pregnancy. However, sustained-release naltrexone implant use in humans has resulted in cases of inadvertent foetal exposure. Here, we used clinically relevant dosing to examine the effects of maternally administered sustained-release naltrexone on the rat brain by examining offspring at birth and in adulthood. Maternal treatment (naltrexone or placebo implant) started before conception and ceased during gestation, birth or weaning. Morphometry was assessed in offspring at birth and adulthood. Adult offspring were evaluated for differences in locomotor behaviour (basal and morphine-induced, 10 mg/kg, s.c.) and opioid neurochemistry, propensity to self-administer morphine and cue-induced drug-seeking after abstinence. Blood analysis confirmed offspring exposure to naltrexone during gestation, birth and weaning. Naltrexone exposure increased litter size and reduced offspring birth-weight but did not alter brain morphometry. Compared to placebo, basal motor activity of naltrexone-exposed adult offspring was lower, yet they showed enhanced development of psychomotor sensitization to morphine. Developmental naltrexone exposure was associated with resistance to morphine-induced down-regulation of striatal preproenkephalin mRNA expression in adulthood. Adult offspring also exhibited greater operant responding for morphine and, in addition, cue-induced drug-seeking was enhanced. Collectively, these data show pronounced effects of developmental naltrexone exposure, some of which persist into adulthood, highlighting the need for follow up of humans that were exposed to naltrexone in utero.
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Registered trials
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