ArticlePloS one2012
The Drosophila actin regulator ENABLED regulates cell shape and orientation during gonad morphogenesis.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
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- The Tbx1 ortholog org-1 is required to establish testis stem cell niche identity in Drosophila.Development (Cambridge, England) · 2026Article
- Ovarian germline stem cell dedifferentiation is cytoneme dependent.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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- Generation ofmicroPublication biology · 2025Article
- An actomyosin network organizes niche morphology and responds to feedback from recruited stem cells.Current biology : CB · 2024Article
- An actomyosin network organizes niche morphology and responds to feedback from recruited stem cells.bioRxiv : the preprint server for biology · 2024Article
- A conserved function of Human DLC3 andeLife · 2022Article
- Visceral mesoderm signaling regulates assembly position and function of the Drosophila testis niche.Developmental cell · 2022Article
- A transitory signaling center controls timing of primordial germ cell differentiation.Developmental cell · 2021Article
- Dissection and Live-Imaging of the Late Embryonic Drosophila Gonad.Journal of visualized experiments : JoVE · 2020Article
- Live imaging reveals hub cell assembly and compaction dynamics during morphogenesis of the Drosophila testis niche.Developmental biology · 2019Article
- Finding their way: themes in germ cell migration.Current opinion in cell biology · 2016Review
- Regulation of Gonad Morphogenesis in Drosophila melanogaster by BTB Family Transcription Factors.PloS one · 2016Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Organs develop distinctive morphologies to fulfill their unique functions. We used Drosophila embryonic gonads as a model to study how two different cell lineages, primordial germ cells (PGCs) and somatic gonadal precursors (SGPs), combine to form one organ. We developed a membrane GFP marker to image SGP behaviors live. These studies show that a combination of SGP cell shape changes and inward movement of anterior and posterior SGPs leads to the compaction of the spherical gonad. This process is disrupted in mutants of the actin regulator, enabled (ena). We show that Ena coordinates these cell shape changes and the inward movement of the SGPs, and Ena affects the intracellular localization of DE-cadherin (DE-cad). Mathematical simulation based on these observations suggests that changes in DE-cad localization can generate the forces needed to compact an elongated structure into a sphere. We propose that Ena regulates force balance in the SGPs by sequestering DE-cad, leading to the morphogenetic movement required for gonad compaction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.