ArticlePloS one2012
Genome-wide search for gene-gene interactions in colorectal cancer.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Trial
- The Dynamic Roles of Repressor Element 1-Silencing Transcription Factor (REST): A Double-Edged Sword in Neural Health and Disease.Molecular neurobiology · 2025Review
- Identification of Driver Epistatic Gene Pairs Combining Germline and Somatic Mutations in Cancer.International journal of molecular sciences · 2023Article
- Impaired delay discounting and time sensitivity in methcathinone use disorder.European archives of psychiatry and clinical neuroscience · 2022Article
- A Large-Scale Genome-Wide Gene-Gene Interaction Study of Lung Cancer Susceptibility in Europeans With a Trans-Ethnic Validation in Asians.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2022Article
- Cancer Risk Score Prediction Based on a Single-Nucleotide Polymorphism Network.Healthcare informatics research · 2022Article
- Long-term association of pregnancy and maternal brain structure: the Rotterdam Study.European journal of epidemiology · 2022Article
- Influence of Arg399Gln, Arg280His and Arg194Trp XRCC1 gene polymorphisms of Base Excision Repair pathway on the level of 8-oxo-guanine and risk of head and neck cancer in the Polish population.Cancer biomarkers : section A of Disease markers · 2021Article
- Genetic susceptibility in the development of colorectal adenomas according to family history of colorectal cancer.International journal of cancer · 2019Article
- Effects of interactions between common genetic variants and alcohol consumption on colorectal cancer risk.Oncotarget · 2018Article
- Effects of interactions between common genetic variants and smoking on colorectal cancer.BMC cancer · 2017Article
- In silico pathway analysis and tissue specific cis-eQTL for colorectal cancer GWAS risk variants.BMC genomics · 2017Article
- Association of genetic polymorphisms with laryngeal carcinoma prognosis in a Chinese population.Oncotarget · 2017Article
- Common risk variants for colorectal cancer: an evaluation of associations with age at cancer onset.Scientific reports · 2017Article
- The genetic heterogeneity of colorectal cancer predisposition - guidelines for gene discovery.Cellular oncology (Dordrecht, Netherlands) · 2016Review
- Gene-gene interactions in gastrointestinal cancer susceptibility.Oncotarget · 2016Review
- Mapping hyper-susceptibility to colitis-associated colorectal cancer in FVB/NJ mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
- Copy number variants associated with 18p11.32, DCC and the promoter 1B region of APC in colorectal polyposis patients.Meta gene · 2016Article
- Identification of a shared protective genetic susceptibility locus for colorectal cancer and gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Genome-Wide Analysis of Gene-Gene and Gene-Environment Interactions Using Closed-Form Wald Tests.Genetic epidemiology · 2015Article
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43 authors.
Funding
Abstract
Genome-wide association studies (GWAS) have successfully identified a number of single-nucleotide polymorphisms (SNPs) associated with colorectal cancer (CRC) risk. However, these susceptibility loci known today explain only a small fraction of the genetic risk. Gene-gene interaction (GxG) is considered to be one source of the missing heritability. To address this, we performed a genome-wide search for pair-wise GxG associated with CRC risk using 8,380 cases and 10,558 controls in the discovery phase and 2,527 cases and 2,658 controls in the replication phase. We developed a simple, but powerful method for testing interaction, which we term the Average Risk Due to Interaction (ARDI). With this method, we conducted a genome-wide search to identify SNPs showing evidence for GxG with previously identified CRC susceptibility loci from 14 independent regions. We also conducted a genome-wide search for GxG using the marginal association screening and examining interaction among SNPs that pass the screening threshold (p<10(-4)). For the known locus rs10795668 (10p14), we found an interacting SNP rs367615 (5q21) with replication p = 0.01 and combined p = 4.19×10(-8). Among the top marginal SNPs after LD pruning (n = 163), we identified an interaction between rs1571218 (20p12.3) and rs10879357 (12q21.1) (nominal combined p = 2.51×10(-6); Bonferroni adjusted p = 0.03). Our study represents the first comprehensive search for GxG in CRC, and our results may provide new insight into the genetic etiology of CRC.
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