ArticlePloS one2012
The influence of cold temperature on cellular excitability of hippocampal networks.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Long-term temperature variability and cognitive performance among mid-to-older-aged adults in China.Scientific reports · 2026Article
- Rhythmic network activity in human brain slices: variability, mechanisms, and translational insights.Frontiers in synaptic neuroscience · 2026Review
- Structure-Function Relationships of KAdvances in experimental medicine and biology · 2026Review
- Focal brain cooling suppresses spreading depolarization and reduces endothelial nitric oxide synthase expression in rats.IBRO neuroscience reports · 2024Article
- Temperature-dependent structural plasticity of hippocampal synapses.Frontiers in cellular neuroscience · 2022Article
- Development-Dependent Plasticity in Vasoactive Intestinal Polypeptide Neurons in the Infralimbic Cortex.Cerebral cortex communications · 2021Article
- Are TREK Channels Temperature Sensors?Frontiers in cellular neuroscience · 2021Review
- Contribution of KCNQ and TREK Channels to the Resting Membrane Potential in Sympathetic Neurons at Physiological Temperature.International journal of molecular sciences · 2020Article
- Chloroform is a potent activator of cardiac and neuronal Kir3 channels.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- TREK-1 Null Impairs Neuronal Excitability, Synaptic Plasticity, and Cognitive Function.Molecular neurobiology · 2020Article
- Effects of Cortical Cooling on Activity Across Layers of the Rat Barrel Cortex.Frontiers in systems neuroscience · 2020Article
- Infrared neural stimulation and inhibition using an implantable silicon photonic microdevice.Microsystems & nanoengineering · 2020Article
- Reduction of spike generation frequency by cooling in brain slices from rats and from patients with epilepsy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- TREK-1 channels regulate pressure sensitivity and calcium signaling in trabecular meshwork cells.The Journal of general physiology · 2018Article
- Effect of temperature on FAD and NADH-derived signals and neurometabolic coupling in the mouse auditory and motor cortex.Pflugers Archiv : European journal of physiology · 2017Article
- Ion channel profile of TRPM8 cold receptors reveals a role of TASK-3 potassium channels in thermosensation.Cell reports · 2014Article
- Temperature sensitivity of two-pore (K2P) potassium channels.Current topics in membranes · 2014Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hippocampus plays an important role in short term memory, learning and spatial navigation. A characteristic feature of the hippocampal region is its expression of different electrical population rhythms and activities during different brain states. Physiological fluctuations in brain temperature affect the activity patterns in hippocampus, but the underlying cellular mechanisms are poorly understood. In this work, we investigated the thermal modulation of hippocampal activity at the cellular network level. Primary cell cultures of mouse E17 hippocampus displayed robust network activation upon light cooling of the extracellular solution from baseline physiological temperatures. The activity generated was dependent on action potential firing and excitatory glutamatergic synaptic transmission. Involvement of thermosensitive channels from the transient receptor potential (TRP) family in network activation by temperature changes was ruled out, whereas pharmacological and immunochemical experiments strongly pointed towards the involvement of temperature-sensitive two-pore-domain potassium channels (K(2P)), TREK/TRAAK family. In hippocampal slices we could show an increase in evoked and spontaneous synaptic activity produced by mild cooling in the physiological range that was prevented by chloroform, a K(2P) channel opener. We propose that cold-induced closure of background TREK/TRAAK family channels increases the excitability of some hippocampal neurons, acting as a temperature-sensitive gate of network activation. Our findings in the hippocampus open the possibility that small temperature variations in the brain in vivo, associated with metabolism or blood flow oscillations, act as a switch mechanism of neuronal activity and determination of firing patterns through regulation of thermosensitive background potassium channel activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.