ArticlePloS one2012
A new migration map of HIV-1 CRF07_BC in China: analysis of sequences from 12 provinces over a decade.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Using molecular network analysis to understand current HIV-1 transmission characteristics in an inland area of Yunnan, China.Epidemiology and infection · 2023Article
- Distribution pattern, molecular transmission networks, and phylodynamic of hepatitis C virus in China.PloS one · 2023Article
- Characterization of two novel HIV-1 second-generation recombinants (CRF01_AE/CRF07_BC) identified in Hebei Province, China.Frontiers in microbiology · 2023Article
- Article
- CRF07_BC is associated with slow HIV disease progression in Chinese patients.Scientific reports · 2022Article
- Unique profile of predominant CCR5-tropic in CRF07_BC HIV-1 infections and discovery of an unusual CXCR4-tropic strain.Frontiers in immunology · 2022Article
- Analysis of the Driving Factors of Active and Rapid Growth Clusters Among CRF07_BC-Infected Patients in a Developed Area in Eastern China.Open forum infectious diseases · 2021Article
- Prevalence and determinants of virological failure, genetic diversity and drug resistance among people living with HIV in a minority area in China: a population-based study.BMC infectious diseases · 2020Article
- Molecular network-based intervention brings us closer to ending the HIV pandemic.Frontiers of medicine · 2020Review
- Overrepresentation of Injection Drug Use Route of Infection Among Human Immunodeficiency Virus Long-term Nonprogressors: A Nationwide, Retrospective Cohort Study in China, 1989-2016.Open forum infectious diseases · 2019Article
- HIV-1 genotype diversity and distribution characteristics among heterosexually transmitted population in Jiangsu province, China.Virology journal · 2019Article
- Increased predominance of HIV-1 CRF01_AE and its recombinants in the Philippines.The Journal of general virology · 2019Article
- Highlighting the crucial role of Hangzhou in HIV-1 transmission among men who have sex with men in Zhejiang, China.Scientific reports · 2017Article
- Geographic origin and evolutionary history of China's two predominant HIV-1 circulating recombinant forms, CRF07_BC and CRF08_BC.Scientific reports · 2016Article
- Diverse origins of hepatitis C virus in HIV co-infected men who have sex with men in Hong Kong.Virology journal · 2015Article
- CRF07_BC Strain Dominates the HIV-1 Epidemic in Injection Drug Users in Liangshan Prefecture of Sichuan, China.AIDS research and human retroviruses · 2015Article
- Prevalence of human immunodeficiency virus 1 infection in the last decade among entry travelers in Yunnan Province, China.BMC public health · 2015Article
- Article
- Impact of clade, geography, and age of the epidemic on HIV-1 neutralization by antibodies.Journal of virology · 2014Article
- Phylogenetic and temporal dynamics of human immunodeficiency virus type 1B in China: four types of B strains circulate in China.AIDS research and human retroviruses · 2014Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs one of prevalence HIV-1 strains in IDUs in Asia, the origination and full transmission map of CRF07_BC is of great interested and remains unclear. In the study, we collected 769 CRF07_BC derived sequences (including 45 sequences generated in our laboratory) from 12 provinces in China for reconstructing transmission map. Meanwhile, ample historic epidemic evidences were also reviewed to assist sequences analysis. METHODOLOGY/PRINCIPAL
findingsIn the study, we collected 769 CRF07_BC derived sequences and identified 138 independent sequences from 12 provinces in China for subsequent phylogeographic tree analysis, Bayes Factor test and the estimation of state tMRCA. The analyses demonstrated that CRF07_BC was originated in 1993 in IDU in Yunnan province and then initially spread to Guangxi (eastern neighbor to Yunnan) in 1994, to Xinjiang (northwest) in 1995 and to Sichuan (northern neighbor to Yunnan) in 1996. The subsequent transmissions occurred from Yunnan to Liaoning (northeast) in 1997 and to Jiangsu in 1998. Interestingly, after the early introduction of CRF07_BC into Guangxi, Xinjiang and Sichuan, these three regions served as secondary epicenters for further spreading into Gansu, Ningxia, Qinghai, Beijing and Hunan during 1999-2001. These analyzed results are in accordance with early epidemic investigations. CONCLUSIONS/SIGNIFICANCE: Our data not just reconstructed the migration map of CRF07_BC, but also firstly revealed the active roles of these secondary epicenters in the dynamic migration of CRF07_BC in China.
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