ArticlePloS one2012
Functional differences between mitochondrial haplogroup T and haplogroup H in HEK293 cybrid cells.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- A replication study and meta-analysis of mitochondrial DNA variants in the radiographic progression of knee osteoarthritis.Rheumatology (Oxford, England) · 2017Pooled it
- Mitochondrial Haplogroups and Left Ventricular Diastolic Dysfunction in People Living With and Without HIV.The Journal of infectious diseases · 2026Article
- Article
- First Latin American Case of MLASA2 Caused by a Pathogenic Variant in the Anticodon-Binding Domain ofInternational journal of molecular sciences · 2025Article
- The contributions of mitochondrial and nuclear mitochondrial genetic variation to neuroticism.Nature communications · 2023Article
- Is there a mitochondrial DNA haplogroup connection between osteoarthritis and elite athletes? A narrative review.RMD open · 2022Review
- Mitochondrial genomic variation in dementia with Lewy bodies: association with disease risk and neuropathological measures.Acta neuropathologica communications · 2022Article
- Neither Donor nor Recipient Mitochondrial Haplotypes Are Associated with Unrelated Donor Transplant Outcomes: A Validation Study from the CIBMTR.Transplantation and cellular therapy · 2021Article
- Molecular Epidemiology of Mitochondrial Cardiomyopathy: A Search Among Mitochondrial and Nuclear Genes.International journal of molecular sciences · 2021Review
- Mitochondria: The Retina's Achilles' Heel in AMD.Advances in experimental medicine and biology · 2021Article
- Association of mitochondrial genomic background with risk of Multiple System Atrophy.Parkinsonism & related disorders · 2020Article
- Mitochondrial DNA in osteoarthritis disease.Clinical rheumatology · 2020Article
- Ischemic Stroke Risk Associated with Mitochondrial Haplogroup F in the Asian Population.Cells · 2020Article
- African and Asian Mitochondrial DNA Haplogroups Confer Resistance Against Diabetic Stresses on Retinal Pigment Epithelial Cybrid Cells In Vitro.Molecular neurobiology · 2020Article
- Mitonuclear interactions influence Alzheimer's disease risk.Neurobiology of aging · 2020Article
- Environmental factors modulated ancient mitochondrial DNA variability and the prevalence of rheumatic diseases in the Basque Country.Scientific reports · 2019Article
- Disease-causing mutations in subunits of OXPHOS complex I affect certain physical interactions.Scientific reports · 2019Article
- Mitochondrial haplogroups are not associated with diabetic retinopathy in a large Australian and British Caucasian sample.Scientific reports · 2019Article
- Review
- Cybrid Models of Pathological Cell Processes in Different Diseases.Oxidative medicine and cellular longevity · 2018Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpidemiological case-control studies have revealed associations between mitochondrial haplogroups and the onset and/or progression of various multifactorial diseases. For instance, mitochondrial haplogroup T was previously shown to be associated with vascular diseases, including coronary artery disease and diabetic retinopathy. In contrast, haplogroup H, the most frequent haplogroup in Europe, is often found to be more prevalent in healthy control subjects than in patient study groups. However, justifications for the assumption that haplogroups are functionally distinct are rare. Therefore, we attempted to compare differences in mitochondrial function between haplogroup H and T cybrids. METHODOLOGY/PRINCIPAL
findingsMitochondrial haplogroup H and T cybrids were generated by fusion of HEK293 cells devoid of mitochondrial DNA with isolated thrombocytes of individuals with the respective haplogroups. These cybrid cells were analyzed for oxidative phosphorylation (OXPHOS) enzyme activities, mitochondrial DNA (mtDNA) copy number, growth rate and susceptibility to reactive oxygen species (ROS). We observed that haplogroup T cybrids have higher survival rate when challenged with hydrogen peroxide, indicating a higher capability to cope with oxidative stress. CONCLUSIONS/SIGNIFICANCE: The results of this study show that functional differences exist between HEK293 cybrid cells which differ in mitochondrial genomic background.
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