ArticlePloS one2012
Decoding hindlimb movement for a brain machine interface after a complete spinal transection.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Transitioning from global to local computational strategies during brain-machine interface learning.Frontiers in neuroscience · 2024Article
- Effect of spinal cord injury on neural encoding of spontaneous postural perturbations in the hindlimb sensorimotor cortex.Journal of neurophysiology · 2021Article
- Hindlimb Somatosensory Information Influences Trunk Sensory and Motor Cortices to Support Trunk Stabilization.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Inhibition of Long-Term Variability in Decoding Forelimb Trajectory Using Evolutionary Neural Networks With Error-Correction Learning.Frontiers in computational neuroscience · 2020Article
- A rodent brain-machine interface paradigm to study the impact of paraplegia on BMI performance.Journal of neuroscience methods · 2018Article
- Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury.Nature communications · 2018Article
- Cortex-dependent recovery of unassisted hindlimb locomotion after complete spinal cord injury in adult rats.eLife · 2017Article
- Restoration of Hindlimb Movements after Complete Spinal Cord Injury Using Brain-Controlled Functional Electrical Stimulation.Frontiers in neuroscience · 2017Article
- Engagement of the Rat Hindlimb Motor Cortex across Natural Locomotor Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Output Properties of the Cortical Hindlimb Motor Area in Spinal Cord-Injured Rats.Journal of neurotrauma · 2015Article
- Brain-controlled muscle stimulation for the restoration of motor function.Neurobiology of disease · 2015Review
- Brain-controlled neuromuscular stimulation to drive neural plasticity and functional recovery.Current opinion in neurobiology · 2015Review
- Toward Building Hybrid Biological/in silico Neural Networks for Motor Neuroprosthetic Control.Frontiers in neurorobotics · 2015Article
- Adaptation to elastic loads and BMI robot controls during rat locomotion examined with point-process GLMs.Frontiers in systems neuroscience · 2015Article
- Dissociating movement from movement timing in the rat primary motor cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Electronic bypass of spinal lesions: activation of lower motor neurons directly driven by cortical neural signals.Journal of neuroengineering and rehabilitation · 2014Article
- A brain-machine-muscle interface for restoring hindlimb locomotion after complete spinal transection in rats.PloS one · 2014Article
- Long term, stable brain machine interface performance using local field potentials and multiunit spikes.Journal of neural engineering · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Stereotypical locomotor movements can be made without input from the brain after a complete spinal transection. However, the restoration of functional gait requires descending modulation of spinal circuits to independently control the movement of each limb. To evaluate whether a brain-machine interface (BMI) could be used to regain conscious control over the hindlimb, rats were trained to press a pedal and the encoding of hindlimb movement was assessed using a BMI paradigm. Off-line, information encoded by neurons in the hindlimb sensorimotor cortex was assessed. Next neural population functions, or weighted representations of the neuronal activity, were used to replace the hindlimb movement as a trigger for reward in real-time (on-line decoding) in three conditions: while the animal could still press the pedal, after the pedal was removed and after a complete spinal transection. A novel representation of the motor program was learned when the animals used neural control to achieve water reward (e.g. more information was conveyed faster). After complete spinal transection, the ability of these neurons to convey information was reduced by more than 40%. However, this BMI representation was relearned over time despite a persistent reduction in the neuronal firing rate during the task. Therefore, neural control is a general feature of the motor cortex, not restricted to forelimb movements, and can be regained after spinal injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.