Trial reportPloS one2012
A variant in the ABO gene explains the variation in soluble E-selectin levels-results from dense genotyping in two independent populations.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns.Journal of medical genetics · 2019Pooled it
- Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator.Nature communications · 2017Trial
- Association of ABO Gene rs2073823 Polymorphism with Microvascular Complications, sP-Selectin Levels and Lipid Profile in Type 2 Diabetes.Current diabetes reviews · 2026Article
- Is ABO blood type a risk factor for adjacent segment degeneration after lumbar spine fusion?European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Machine Learning Approach for Cardiovascular Death Prediction among Nonalcoholic Steatohepatitis (NASH) Liver Transplant Recipients.Healthcare (Basel, Switzerland) · 2024Article
- ABO blood group and COVID-19: a review on behalf of the ISBT COVID-19 Working Group.Vox sanguinis · 2021Review
- Low testosterone concentrations and prediction of future heart failure in men and in women: evidence from the large FINRISK97 study.ESC heart failure · 2021Article
- Associations between smoking and blood-group, and the risk of dyslipidaemia amongst French women.Scientific reports · 2021Article
- Multifaceted role of glycosylation in transfusion medicine, platelets, and red blood cells.Journal of thrombosis and haemostasis : JTH · 2020Review
- Relationship between ABO blood groups and cardiovascular disease in type 1 diabetes according to diabetic nephropathy status.Cardiovascular diabetology · 2020Observational
- Predictive value of low testosterone concentrations regarding coronary heart disease and mortality in men and women - evidence from the FINRISK97 study.Journal of internal medicine · 2019Article
- Whole genome sequence association with E-selectin levels reveals loss-of-function variant in African Americans.Human molecular genetics · 2019Article
- Article
- Soluble vascular cell adhesion molecular-1 is a potential biological indicator of hemophilic arthropathy.Medicine · 2016Observational
- ABO blood group associations with markers of endothelial dysfunction in the Multi-Ethnic Study of Atherosclerosis.Atherosclerosis · 2016Article
- The relationship between ABO blood group and cardiovascular disease: results from the Cardiorisk program.Annals of translational medicine · 2016Article
- Role of E-selectin for diagnosis of myocardial injury in children of age up to 14 years.International journal of clinical and experimental pathology · 2015Article
- The ABO blood group predicts survival in esophageal squamous cell carcinoma in patients who ever smoked: a retrospective study from China.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Possible role of ABO system in age-related diseases and longevity: a narrative review.Immunity & ageing : I & A · 2014Review
- Pro-inflammatory genetic markers of atherosclerosis.Current atherosclerosis reports · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElevated soluble (s) E-selectin levels have been associated with various cardiovascular diseases. Recently, genetic variants in the ABO blood group have been related to E-selectin levels in a small cohort of patients with type 1 diabetes. We evaluated whether this association is reproducible in two large samples of Caucasians. METHODOLOGY/ PRINCIPAL
findingsData of the present study was drawn from the population-based MONICA/KORA Augsburg study (n = 1,482) and the patients-based LURIC study (n = 1,546). A high-density genotyping array (50K IBC Chip) containing single-nucleotide polymorphisms (SNPs) from E-selectin candidate genes selected on known biology of E-selectin metabolism, mouse genetic studies, and human genetic association studies, was used for genotyping. Linear regression analyses with adjustment for age and sex (and survey in KORA) were applied to assess associations between gene variants and sE-selectin concentrations. A number of 12 SNPs (in KORA) and 13 SNPs (in LURIC), all from the ABO blood group gene, were significantly associated with the log-transformed concentration of E-selectin. The strongest association was observed for rs651007 with a change of log-transformed sE-selectin per one copy of the minor allele of -0.37 ng/ml (p = 1.87×10(-103)) in KORA and -0.35 ng/ml (p = 5.11×10(-84)) in LURIC. Inclusion of rs651007 increased the explained sE-selectin variance by 0.256 in KORA and 0.213 in LURIC. All SNPs had minor allele frequencies above 20% showing a substantial gene variation. CONCLUSIONS/ SIGNIFICANCE: Our findings in two independent samples indicate that the genetic variants at the ABO locus affect sE-selectin levels. Since distinct genome-wide association studies linked the ABO gene with myocardial infarction (MI) in the presence of coronary atherosclerosis and with coronary artery disease, these findings may not only enhance our understanding of adhesion molecule biology, but may also provide a focus for several novel research avenues.
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