ArticlePloS one2012
Early differential gene expression in haemocytes from resistant and susceptible Biomphalaria glabrata strains in response to Schistosoma mansoni.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 64 citations in OpenAlex.
- Schistosome species, parasite development, and co-infection combinations determine microbiome dynamics in the snail Biomphalaria glabrata.Animal microbiome · 2025Article
- Exploring the genome-wide transcriptomic responses of Bulinus truncatus to Schistosoma haematobium infection: An important host-parasite system involved in the transmission of human urogenital schistosomiasis.Molecular immunology · 2024Article
- Nuclear genome of Bulinus truncatus, an intermediate host of the carcinogenic human blood fluke Schistosoma haematobium.Nature communications · 2022Article
- Molecular characterization of thioester-containing proteins inFrontiers in immunology · 2022Article
- Immunological Resistance ofFrontiers in immunology · 2022Review
- Clustered Regularly Interspaced Short Palindromic Repeats/ CRISPR associated protein 9-mediated editing of Schistosoma mansoni genes: Identifying genes for immunologically potent drug and vaccine development.Revista da Sociedade Brasileira de Medicina Tropical · 2022Review
- An Overview of Transcriptional Responses of Schistosome-Susceptible (M line) or -Resistant (BS-90)Frontiers in immunology · 2021Article
- Article
- Diminished adherence of Biomphalaria glabrata embryonic cell line to sporocysts of Schistosoma mansoni following programmed knockout of the allograft inflammatory factor.Parasites & vectors · 2020Article
- Heat shock increases hydrogen peroxide release from circulating hemocytes of the snail Biomphalaria glabrata.Fish & shellfish immunology · 2020Article
- Biomphalaria glabrata immunity: Post-genome advances.Developmental and comparative immunology · 2020Review
- Article
- Glabralysins, Potential New β-Pore-Forming Toxin Family Members from the Schistosomiasis Vector SnailGenes · 2020Article
- Sympatric versus allopatric evolutionary contexts shape differential immune response in Biomphalaria / Schistosoma interaction.PLoS pathogens · 2019Article
- Analysis of Predicted Host-Parasite Interactomes Reveals Commonalities and Specificities Related to Parasitic Lifestyle and Tissues Tropism.Frontiers in immunology · 2019Article
- Treading the Path towards Genetic Control of Snail Resistance to Schistosome Infection.Tropical medicine and infectious disease · 2018Review
- Proteomic Analysis ofFrontiers in immunology · 2018Article
- Comparative immunogenomics of molluscs.Developmental and comparative immunology · 2017Review
- A multistrain approach to studying the mechanisms underlying compatibility in the interaction between Biomphalaria glabrata and Schistosoma mansoni.PLoS neglected tropical diseases · 2017Article
- Microbial Pre-exposure and Vectorial Competence ofFrontiers in cellular and infection microbiology · 2017Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
The outcome of infection in the host snail Biomphalaria glabrata with the digenean parasite Schistosoma mansoni is determined by the initial molecular interplay occurring between them. The mechanisms by which schistosomes evade snail immune recognition to ensure survival are not fully understood, but one possibility is that the snail internal defence system is manipulated by the schistosome enabling the parasite to establish infection. This study provides novel insights into the nature of schistosome resistance and susceptibility in B. glabrata at the transcriptomic level by simultaneously comparing gene expression in haemocytes from parasite-exposed and control groups of both schistosome-resistant and schistosome-susceptible strains, 2 h post exposure to S. mansoni miracidia, using an novel 5K cDNA microarray. Differences in gene expression, including those for immune/stress response, signal transduction and matrix/adhesion genes were identified between the two snail strains and tests for asymmetric distributions of gene function also identified immune-related gene expression in resistant snails, but not in susceptible. Gene set enrichment analysis revealed that genes involved in mitochondrial electron transport, ubiquinone biosynthesis and electron carrier activity were consistently up-regulated in resistant snails but down-regulated in susceptible. This supports the hypothesis that schistosome-resistant snails recognize schistosomes and mount an appropriate defence response, while in schistosome-susceptible snails the parasite suppresses this defence response, early in infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.