ArticlePLoS computational biology2012
Calcium wave propagation in networks of endothelial cells: model-based theoretical and experimental study.
Article in PLoS computational biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Calcium waves and nuclear tension changes coordinate mechanical stress dissipation in locally folded epithelia.iScience · 2026Article
- Endothelial calcium dynamics elicited by ATP release from red blood cells.Scientific reports · 2024Article
- Heterogeneous ATP patterns in microvascular networks.Journal of the Royal Society, Interface · 2023Article
- Integration of reconfigurable microchannels into aligned three-dimensional neural networks for spatially controllable neuromodulation.Science advances · 2023Article
- Intercellular water exchanges trigger soliton-like waves in multicellular systems.Biophysical journal · 2022Article
- Cataract Progression Associated with Modifications in Calcium Signaling in Human Lens Epithelia as Studied by Mechanical Stimulation.Life (Basel, Switzerland) · 2021Article
- Cellular Architecture Regulates Collective Calcium Signaling and Cell Contractility.PLoS computational biology · 2016Article
- Probing Leader Cells in Endothelial Collective Migration by Plasma Lithography Geometric Confinement.Scientific reports · 2016Article
- Patterning of wound-induced intercellular Ca(2+) flashes in a developing epithelium.Physical biology · 2015Article
- Probing mechanoregulation of neuronal differentiation by plasma lithography patterned elastomeric substrates.Scientific reports · 2014Article
- Phase transitions in the multi-cellular regulatory behavior of pancreatic islet excitability.PLoS computational biology · 2014Article
- Dimensionality and size scaling of coordinated Ca(2+) dynamics in MIN6 β-cell clusters.Biophysical journal · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
In this paper, we present a combined theoretical and experimental study of the propagation of calcium signals in multicellular structures composed of human endothelial cells. We consider multicellular structures composed of a single chain of cells as well as a chain of cells with a side branch, namely a "T" structure. In the experiments, we investigate the result of applying mechano-stimulation to induce signaling in the form of calcium waves along the chain and the effect of single and dual stimulation of the multicellular structure. The experimental results provide evidence of an effect of architecture on the propagation of calcium waves. Simulations based on a model of calcium-induced calcium release and cell-to-cell diffusion through gap junctions shows that the propagation of calcium waves is dependent upon the competition between intracellular calcium regulation and architecture-dependent intercellular diffusion.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.