Evidence map›Paper›PMID 23300345›Full record

ArticleBioinformatics and biology insights2012

Methods of combinatorial optimization to reveal factors affecting gene length.

Alexander Bolshoy, Tatiana Tatarinova

Abstract read
In one paragraph

Article in Bioinformatics and biology insights, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Gene-Family Extension Measures and Correlations.Life (Basel, Switzerland) · 2016
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alexander BolshoyDepartment of Evolutionary and Environmental Biology and Institute of Evolution, University of Haifa, Israel. ; Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Tatiana Tatarinova

Funding

Populaton Pharmacokinetic Modeling and Optimal ControlR01GM068968 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NEELY, MICHAEL N. · 2003 to 2015
$3.9M
Ontogeny of Voriconazole Pharmaockinetics and MetabolismR01HD070886 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NEELY, MICHAEL N. · 2012 to 2016
$2.5M
NICHD NIH HHS R01 HD070886NIGMS NIH HHS R01 GM068968
6 · The paper itself

Abstract

In this paper we present a novel method for genome ranking according to gene lengths. The main outcomes described in this paper are the following: the formulation of the genome ranking problem, presentation of relevant approaches to solve it, and the demonstration of preliminary results from prokaryotic genomes ordering. Using a subset of prokaryotic genomes, we attempted to uncover factors affecting gene length. We have demonstrated that hyperthermophilic species have shorter genes as compared with mesophilic organisms, which probably means that environmental factors affect gene length. Moreover, these preliminary results show that environmental factors group together in ranking evolutionary distant species.

Indexed as

adaptationclusteringdimension-reduction techniquesevolution of prokaryotesfactor analysismachine learningorthologsrankingrating

Identifiers

PMID23300345
PMCPMC3528112

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.