Trial reportNeurorehabilitation and neural repair2013
Priming pharyngeal motor cortex by repeated paired associative stimulation: implications for dysphagia neurorehabilitation.
Trial report in Neurorehabilitation and neural repair, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Transcranial Direct Current Stimulation Over the Vagus Nerve Promotes Poststroke Dysphagia Recovery: A Randomized, Double-Blind, Sham-Controlled Clinical Trial.American journal of physical medicine & rehabilitation · 2026Trial
- Post-extubation dysphagia in the ICU-a narrative review: epidemiology, mechanisms and clinical management (Update 2025).Critical care (London, England) · 2025Review
- Risk Factors for Oropharyngeal Dysphagia in Older Adults - Evidence from Consorci Sanitari Del Maresme and Mataró University Hospital, Catalonia, Spain.Aging and disease · 2025Article
- Research progress of clinical intervention and nursing for patients with post-stroke dysphagia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Best Practice Recommendations for Geriatric Dysphagia Management with 5 Ws and 1H.Annals of geriatric medicine and research · 2022Article
- Metaplasticity in the human swallowing system: clinical implications for dysphagia rehabilitation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Post-stroke Dysphagia: Recent Insights and Unanswered Questions.Current neurology and neuroscience reports · 2020Review
- Convergent Associative Motor Cortical Plasticity Induced by Conditional Somatosensory and Motor Reaction Afferents.Frontiers in human neuroscience · 2020Article
- Application of noninvasive brain stimulation for post-stroke dysphagia rehabilitation.The Kaohsiung journal of medical sciences · 2017Review
- European Society for Swallowing Disorders - European Union Geriatric Medicine Society white paper: oropharyngeal dysphagia as a geriatric syndrome.Clinical interventions in aging · 2016Review
- Article
- Induction of plasticity in the human motor cortex by pairing an auditory stimulus with TMS.Frontiers in human neuroscience · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundSeveral stimulation parameters can influence the neurophysiological and behavioral effects of paired associative stimulation (PAS), a neurostimulation paradigm that repeatedly pairs a peripheral electrical with a central cortical (transcranial magnetic stimulation [TMS]) stimulus. This also appears to be the case when PAS is applied to the pharyngeal motor cortex (MI), with some variability in excitatory responses, questioning its translation into a useful therapy for patients with brain injury.
objectiveTo investigate whether repeated PAS in both "responders" and "nonresponders" could enhance cortical excitability in pharyngeal MI more robustly.
methodsBased on their responses after single PAS, healthy participants were stratified into 2 groups of "responders" and "nonresponders" and underwent 2 periods (60 minutes inter-PAS interval) of active and sham PAS in a randomized order. Neurophysiological measurements with single TMS pulses from pharyngeal motor representation were collected up to 90 minutes after the second PAS period.
resultsRepeated PAS increased cortical excitability up to 95% at 60 minutes following the second PAS in both the "responders" and "nonresponders." Moreover, cortical excitability in the "nonresponders" was significantly different after repeated PAS compared with single and sham application (P = .02; z = -2.2).
conclusionsDouble dose PAS switched "nonresponders" to "responders." These results are important for PAS application to dysphagic stroke patients who do not initially respond to a single application.
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