Trial reportJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2013
Cystatin C and risk of hip fractures in older women.
Trial report in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Association of Increased Urinary Albumin With Risk of Incident Clinical Fracture and Rate of Hip Bone Loss: the Osteoporotic Fractures in Men Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Trial
- Genome-wide association study of molecular markers related to keel length in a specialized strain of yellow feathered broilers.Poultry science · 2026Article
- Serum cystatin C as a biomarker to predict all-cause mortality in geriatrics hip fracture.Heliyon · 2024Article
- Proteinuria screening and risk of bone fracture: a retrospective cohort study using a nationwide population-based database.Clinical kidney journal · 2024Article
- Management of patients at very high risk of osteoporotic fractures through sequential treatments.Aging clinical and experimental research · 2022Review
- Kidney function and its association to imminent, short- and long-term fracture risk-a longitudinal study in older women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Utility of the Serum Cystatin C Level for Diagnosis of Osteoporosis among Middle-Aged and Elderly People.BioMed research international · 2019Article
- A Study of the Relationship Between Cystatin C and Metabolic Bone Disease in Preterm InfantsJournal of clinical research in pediatric endocrinology · 2018Article
- Hip fracture incidence and mortality in chronic kidney disease: the GLOMMS-II record linkage cohort study.BMJ open · 2018Article
- Evaluation of fracture risk in chronic kidney disease.Journal of nephrology · 2017Review
- Cystatin C and the Risk of Frailty and Mortality in Older Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Cystatin C is Better than Serum Creatinine for Estimating Glomerular Filtration Rate to Detect Osteopenia in Chronic Kidney Disease Patients.Yonsei medical journal · 2017Article
- Association between serum cystatin C and bone mineral density in Korean adults.Therapeutics and clinical risk management · 2017Article
- Observational
- Inflammatory markers and risk of hip fracture in older white women: the study of osteoporotic fractures.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- Low holotranscobalamin and cobalamins predict incident fractures in elderly men: the MrOS Sweden.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- Estimated GFR and risk of hip fracture in older men: comparison of associations using cystatin C and creatinine.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2014Article
- Fracture risk in CKD.Clinical journal of the American Society of Nephrology : CJASN · 2013Article
- Bone: cystatin C-a biomarker of hip fracture risk?Nature reviews. Endocrinology · 2013Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
To test the hypothesis that older women with higher cystatin C are at increased risk of hip fracture independent of traditional risk factors including hip bone mineral density (BMD), we performed a case-cohort analysis nested in a cohort of 4709 white women attending a Year 10 (1997-1998) examination of the Study of Osteoporotic Fractures that included a random sample of 1170 women and the first 300 women with incident hip fracture occurring after Year 10 examination. Serum cystatin C and creatinine were measured in Year 10 sera. In a model adjusted for age, clinical site, body mass index, and total hip BMD, higher cystatin C was associated with an increased risk of hip fracture (p for linear trend 0.008) with women in quartile 4 having a 1.9-fold higher risk (hazard ratio [HR] 1.91; 95% confidence interval [CI], 1.24-2.95) compared with those in quartile 1 (referent group). Further adjustment for additional risk factors only slightly attenuated the association; the risk for hip fracture was 1.7-fold higher (HR 1.74; 95% CI, 1.11-2.72) in women in quartile 4 compared with those in quartile 1. In contrast, neither serum creatinine nor creatinine-based estimated glomerular filtration rate (eGFRCr ) were associated with risk of hip fracture. Older women with higher cystatin C, but not higher serum creatinine or lower eGFRCr , have an increased risk of hip fracture independent of traditional risk factors. These findings suggest that cystatin C may be a promising biomarker for identification of older adults at high risk of hip fracture.
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