ArticleBehavior genetics2013
Shared and distinct genetic influences among different measures of pulmonary function.
Article in Behavior genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Relationship between respiratory function assessed by spirometry and mild cognitive impairment among community-dwelling older adults.Geriatrics & gerontology international · 2024Article
- Gender influence on the MVV / FEVı ratio in a population of healthy young adults.Physiological reports · 2020Article
- Article
- Individual differences in cognitive ability at age 20 predict pulmonary function 35 years later.Journal of epidemiology and community health · 2015Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
We examined shared and distinct genetic influences among standard measures of pulmonary functions: ratio of forced expiratory volume at 1 s to forced vital capacity (FEV1/FVC) and percent predicted values for forced expiratory volume at 1 s (FEV1%p), forced expiratory flow (FEFmax%p), and maximal voluntary ventilation (MVV%p) in 978-1,048 middle-aged (mean age = 55 years) male-male twins from the Vietnam Era Twin Study of Aging. A common latent factor (h(2) = 0.30) accounted for the correlations among these measures. This factor accounted for 54-81 % of the heritability of FEV1%p, FEFmax%p and MVV%p, but only explained 16 % of the heritability of FEV1/FVC. The remaining heritability of FEV1/FVC was explained by genetic influences independent of the common factor. Our findings suggest that while a common latent phenotype accounts for the relationships among different pulmonary function measures, the majority of genetic influences underlying FEV1/FVC--an index of pulmonary obstruction--are distinct from those underlying other pulmonary function measures.
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Registered trials
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