ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013
Altered cerebral response during cognitive control: a potential indicator of genetic liability for schizophrenia.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Alterations in Task-Related Brain Activation in Children, Adolescents and Young Adults at Familial High-Risk for Schizophrenia or Bipolar Disorder - A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- Nimodipine improves cortical efficiency during working memory in healthy subjects.Translational psychiatry · 2020Trial
- Effects of neuregulin 3 genotype on human prefrontal cortex physiology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Trial
- Parental broad autism phenotype traits and executive function in families of children with autism spectrum disorder.Frontiers in psychiatry · 2026Article
- Prenatal environmental risk for adolescent attention, thought, and substance use problems: A mixtures approach to coexposure and psychiatric comorbidities.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Executive Control and Associated Brain Activity in Children With Familial High-Risk of Schizophrenia or Bipolar Disorder: A Danish Register-based Study.Schizophrenia bulletin · 2024Article
- Neuroimaging features of cognitive impairments in schizophrenia and major depressive disorder.Therapeutic advances in psychopharmacology · 2024Review
- Evaluation of data imputation strategies in complex, deeply-phenotyped data sets: the case of the EU-AIMS Longitudinal European Autism Project.BMC medical research methodology · 2022Article
- Neural Basis of Ambivalence towards Ideal Self-Image in Schizophrenia.Psychiatry investigation · 2020Article
- Hippocampal Resting State Functional Connectivity in Patients With Schizophrenia and Unaffected Family Members.Frontiers in psychiatry · 2020Article
- Effects of BDNF ValNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- The use of antioxidant compounds in the treatment of first psychotic episode: Highlights from preclinical studies.CNS neuroscience & therapeutics · 2018Review
- Impaired cortico-limbic functional connectivity in schizophrenia patients during emotion processing.Social cognitive and affective neuroscience · 2018Article
- Enhancing the Informativeness and Replicability of Imaging Genomics Studies.Biological psychiatry · 2017Review
- Deficits in Response Inhibition in Patients with Attention-Deficit/Hyperactivity Disorder: The Impaired Self-Protection System Hypothesis.Frontiers in psychiatry · 2017Article
- Transdiagnostic neural markers of emotion-cognition interaction in psychotic disorders.Journal of abnormal psychology · 2016Article
- Proactive response inhibition abnormalities in the sensorimotor cortex of patients with schizophrenia.Journal of psychiatry & neuroscience : JPN · 2016Article
- Aberrant network connectivity during error processing in patients with schizophrenia.Journal of psychiatry & neuroscience : JPN · 2016Article
- Seeking Optimal Region-Of-Interest (ROI) Single-Value Summary Measures for fMRI Studies in Imaging Genetics.PloS one · 2016Article
- Cigarette Cravings, Impulsivity, and the Brain.Frontiers in psychiatry · 2015Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Aberrant activity in brain regions underlying various aspects of executive cognition has been reported in patients with schizophrenia and in their healthy relatives, suggesting an association with genetic liability. The aim of this study was to investigate brain responses to selective aspects of cognitive control in unaffected siblings who are at increased genetic risk of schizophrenia. Altogether, 65 non-affected siblings, 70 patients with schizophrenia spectrum disorders, and 235 normal controls participated in this study. Blood-oxygen-level-dependent functional magnetic resonance imaging was conducted while participants performed a cognitive control task ('flanker task') to identify brain activity and connectivity associated with response inhibition and conflict monitoring, and suppression. Behaviorally, similar to patients with schizophrenia, siblings were less accurate when inhibiting prepotent responses relative to normal controls. During response inhibition, again similar to patients with schizophrenia, siblings showed decreased activity in the anterior cingulate (ACC), along with increased functional coupling with the dorsolateral prefrontal cortex (PFC) when compared to normal controls. Our findings show altered ACC activity and PFC connectivity in unaffected siblings and patients with schizophrenia during response inhibition. These results suggest that such changes in the neural activity underlying aspects of cognitive control may represent a potential intermediate phenotype for the investigation of the genetic basis of schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.