ArticleNature communications2013
Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation.
Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Regulation of Adaptive Immunity by Lipid Post-translational Modifications.Immune network · 2025Review
- Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer.Science advances · 2024Article
- Regulation of BCR-dependent germinal center B-cell formation by HGAL and insight into its emerging myeloid ortholog, C1ORF150.Frontiers in immunology · 2024Review
- HGAL inhibits lymphoma dissemination by interacting with multiple cytoskeletal proteins.Blood advances · 2021Article
- Conditional expression of HGAL leads to the development of diffuse large B-cell lymphoma in mice.Blood · 2021Article
- Article
- Recent BCR stimulation induces a negative autoregulatory loop via FBXO10 mediated degradation of HGAL.Leukemia · 2020Article
- Protein Palmitoylation in Leukocyte Signaling and Function.Frontiers in cell and developmental biology · 2020Review
- Interplay between HGAL and Grb2 proteins regulates B-cell receptor signaling.Blood advances · 2019Article
- The transcriptional response of mouse spleen B cells to IL-4: Comparison to the response of human peripheral blood B cells.Biochemistry and biophysics reports · 2018Article
- The Making of Leukemia.International journal of molecular sciences · 2018Review
- Galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-γ.Nature communications · 2018Article
- Could Vitamin D Analogues Be Used to Target Leukemia Stem Cells?International journal of molecular sciences · 2016Review
- Is lineage decision-making restricted during tumoral reprograming of haematopoietic stem cells?Oncotarget · 2015Review
- Pre-malignant lymphoid cells arise from hematopoietic stem/progenitor cells in chronic lymphocytic leukemia.International journal of hematology · 2015Review
- Chlamydophila psittaci-negative ocular adnexal marginal zone lymphomas express self polyreactive B-cell receptors.Leukemia · 2015Article
- Article
- Gene expression profile analysis identifies metastasis and chemoresistance-associated genes in epithelial ovarian carcinoma cells.Medical oncology (Northwood, London, England) · 2015Article
- A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks.Nature genetics · 2014Article
- Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma.Nature communications · 2014Article
Corrections and comments
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Authors and funding
23 authors at 8 institutions in 2 countries.
Funding
Abstract
The human germinal centre-associated lymphoma gene is specifically expressed in germinal centre B-lymphocytes and germinal centre-derived B-cell lymphomas, but its function is largely unknown. Here we demonstrate that human germinal centre-associated lymphoma directly binds to Syk in B cells, increases its kinase activity on B-cell receptor stimulation and leads to enhanced activation of Syk downstream effectors. To further investigate these findings in vivo, human germinal centre-associated lymphoma transgenic mice were generated. Starting from 12 months of age these mice developed polyclonal B-cell lymphoid hyperplasia, hypergammaglobulinemia and systemic reactive amyloid A (AA) amyloidosis, leading to shortened survival. The lymphoid hyperplasia in the human germinal centre-associated lymphoma transgenic mice are likely attributable to enhanced B-cell receptor signalling as shown by increased Syk phosphorylation, ex vivo B-cell proliferation and increased RhoA activation. Overall, our study shows for the first time that the germinal centre protein human germinal centre-associated lymphoma regulates B-cell receptor signalling in B-lymphocytes which, without appropriate control, may lead to B-cell lymphoproliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.