ArticleNature communications2013
Extensive diversification of IgH subclass-encoding genes and IgM subclass switching in crocodilians.
Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 40 citations in OpenAlex.
- Post-translational cleavage generates truncated IgY forms in the snakeZoological research · 2025Article
- How Alligator Immune Peptides Kill Gram-Negative Bacteria: A Lipid-Scrambling, Squeezing, and Extracting Mechanism Revealed by Theoretical Simulations.International journal of molecular sciences · 2023Article
- Organization and Complexity of the Yak (Bos Grunniens) Immunoglobulin Loci.Frontiers in immunology · 2022Article
- Deimination Protein Profiles inFrontiers in immunology · 2020Article
- The Unusual Genetics and Biochemistry of Bovine Immunoglobulins.Advances in immunology · 2018Article
- Tracing the Origins of IgE, Mast Cells, and Allergies by Studies of Wild Animals.Frontiers in immunology · 2017Review
- Three IgH isotypes, IgM, IgA and IgY are expressed in Gentoo penguin and zebra finch.PloS one · 2017Article
- Article
- The immunoglobulins of cold-blooded vertebrates.Biomolecules · 2014Review
- Intraclass diversification of immunoglobulin heavy chain genes in the African lungfish.Immunogenetics · 2014Article
- Defense genes missing from the flight division.Developmental and comparative immunology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crocodilians are a group of reptiles that are closely related to birds and are thought to possess a strong immune system. Here we report that the IgH locus in the Siamese crocodile and the Chinese alligator contains multiple μ genes, in contrast to other tetrapods. Both the μ2 and μ3 genes are expressed through class-switch recombination involving the switch region and germline transcription. Both IgM1 and IgM2 are present in the serum as polymers, which implies that IgM class switching may have significant roles in humoural immunity. The crocodilian α genes are the first IgA-encoding genes identified in reptiles, and these genes show an inverted transcriptional orientation similar to that of birds. The identification of both α and δ genes in crocodilians suggests that the IgH loci of modern living mammals, reptiles and birds share a common ancestral organization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.