ReviewCurrent neurology and neuroscience reports2013
Biomarkers and predictors of restorative therapy effects after stroke.
Review in Current neurology and neuroscience reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The modulatory effects of bilateral arm training (BAT) on the brain in stroke patients: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Pooled it
- Are we armed with the right data? Pooled individual data review of biomarkers in people with severe upper limb impairment after stroke.NeuroImage. Clinical · 2017Pooled it
- Variability in stroke motor outcome is explained by structural and functional integrity of the motor system.Scientific reports · 2018Trial
- Biomarkers of Rehabilitation Therapy Vary according to Stroke Severity.Neural plasticity · 2018Trial
- The Effects of Stroke Type, Locus, and Extent on Long-Term Outcome of Gait Rehabilitation: The LEAPS Experience.Neurorehabilitation and neural repair · 2016Trial
- Review
- Review
- Cross-Frequency Coupling as a Biomarker for Early Stroke Recovery.Neurorehabilitation and neural repair · 2024Article
- The Effects of Four Weeks of Chiropractic Spinal Adjustments on Blood Biomarkers in Adults with Chronic Stroke: Secondary Outcomes of a Randomized Controlled Trial.Journal of clinical medicine · 2022Article
- Elevated C-Reactive Protein in Alzheimer's Disease Without Depression in Older Adults: Findings From the Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Machine Learning Methods Predict Individual Upper-Limb Motor Impairment Following Therapy in Chronic Stroke.Neurorehabilitation and neural repair · 2020Article
- Brain Functional Reserve in the Context of Neuroplasticity after Stroke.Neural plasticity · 2019Review
- Targeted Vagus Nerve Stimulation for Rehabilitation After Stroke.Frontiers in neuroscience · 2019Review
- White Matter Biomarkers Associated with Motor Change in Individuals with Stroke: A Continuous Theta Burst Stimulation Study.Neural plasticity · 2019Article
- Neuroimaging Identifies Patients Most Likely to Respond to a Restorative Stroke Therapy.Stroke · 2018Article
- Technological Approaches for Neurorehabilitation: From Robotic Devices to Brain Stimulation and Beyond.Frontiers in neurology · 2018Article
- Importance of Angiogenin and Endothelial Progenitor Cells After Rehabilitation Both in Ischemic Stroke Patients and in a Mouse Model of Cerebral Ischemia.Frontiers in neurology · 2018Article
- Effects of somatosensory electrical stimulation on motor function and cortical oscillations.Journal of neuroengineering and rehabilitation · 2017Article
- PREP2: A biomarker-based algorithm for predicting upper limb function after stroke.Annals of clinical and translational neurology · 2017Article
- Stroke Recovery and Rehabilitation Research: Issues, Opportunities, and the National Institutes of Health StrokeNet.Stroke · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Many restorative therapies that promote brain repair are under development. Stroke is very heterogeneous, highlighting the need to identify target populations and to understand intersubject differences in treatment response. Several neuroimaging measures have shown promise as biomarkers and predictors, including measures of structure and function, in gray matter and white matter. The choice of biomarker and predictor can differ with the content of therapy and with the population under study, for example, contralesional hemisphere measures may be of particular importance in patients with more severe injury. Studies of training effects in healthy subjects provide insights useful to brain repair. Limitations of published studies include a focus on chronic stroke, however the brain is most galvanized to respond to restorative therapies in the early days after stroke. Multimodal approaches might be the most robust approach for stratifying patients and so for optimizing prescription of restorative therapies after stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.